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XB-ART-34825
Dev Biol February 15, 2007; 302 (2): 477-93.

PP2A:B56epsilon is required for eye induction and eye field separation.

Rorick AM , Mei W , Liette NL , Phiel C , El-Hodiri HM , Yang J .


Abstract
Eye induction and eye field separation are the earliest events during vertebrate eye development. Both of these processes occur much earlier than the formation of optic vesicles. The insulin-like growth factor (IGF) pathway appears to be essential for eye induction, yet it remains unclear how IGF downstream pathways are involved in eye induction. As a consequence of eye induction, a single eye anlage is specified in the anterior neural plate. Subsequently, this single eye anlage is divided into two symmetric eye fields in response to Sonic Hedgehog (Shh) secreted from the prechordal mesoderm. Here, we report that B56epsilon regulatory subunit of protein phosphatase 2A (PP2A) is involved in Xenopus eye induction and subsequent eye field separation. We provide evidence that B56epsilon is required for the IGF/PI3K/Akt pathway and that interfering with the PI3K/Akt pathway inhibits eye induction. In addition, we show that B56epsilon regulates the Hedgehog (Hh) pathway during eye field separation. Thus, B56epsilon is involved in multiple signaling pathways and plays critical roles during early development.

PubMed ID: 17074314
Article link: Dev Biol

Genes referenced: akt1 arhgef7 arx cer1 chdh chrd.1 dkk1 eomes foxa2 gal.2 gli1 gli3 gsc igf1 ins kif11 lhx2 mapk1 myc myod1 nodal nodal1 odc1 otx2 pax2 pax6 pik3ca pik3cb pik3cg ptch1 ptch2 ptpa rax shh six3 six6 smo sox3 tbx2


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