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XB-ART-34897
Kidney Int 2006 Oct 01;708:1391-2. doi: 10.1038/sj.ki.5001860.
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Regulation of ENaCs by proteases: An increasingly complex story.

Kleyman TR , Myerburg MM , Hughey RP .


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Proteolytic processing of epithelial Na+ channel (ENaC) subunits has an important role in the regulation of ENaC gating. This Commentary addresses the potential roles of specific proteases and protease inhibitors in the control of Na+ channel gating.

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References :
Wakida, Inhibition of prostasin-induced ENaC activities by PN-1 and regulation of PN-1 expression by TGF-beta1 and aldosterone. 2006, Pubmed, Xenbase