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XB-ART-3500
Cell 2004 May 28;1175:555-6. doi: 10.1016/j.cell.2004.05.005.
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Checkpoint adaptation; molecular mechanisms uncovered.

Lupardus PJ , Cimprich KA .


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Adaptation to the DNA damage checkpoint is a phenomenon long thought to be confined to the unicellular world. A new report in this issue of Cell by suggests the presence of a checkpoint adaptation pathway in Xenopus egg extracts that displays interesting molecular parallels to adaptation in yeast.

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References :
Yoo, Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase. 2004, Pubmed, Xenbase