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Development. July 1, 2006; 133 (13): 2575-84.

TBX5 is required for embryonic cardiac cell cycle progression.

Goetz SC , Brown DD , Conlon FL .

Despite the critical importance of TBX5 in normal development and disease, relatively little is known about the mechanisms by which TBX5 functions in the embryonic heart. Our present studies demonstrate that TBX5 is necessary to control the length of the embryonic cardiac cell cycle, with depletion of TBX5 leading to cardiac cell cycle arrest in late G(1)- or early S-phase. Blocking cell cycle progression by TBX5 depletion leads to a decrease in cardiac cell number, an alteration in the timing of the cardiac differentiation program, defects in cardiac sarcomere formation, and ultimately, to cardiac programmed cell death. In these studies we have also established that terminally differentiated cardiomyocytes retain the capacity to undergo cell division. We further show that TBX5 is sufficient to determine the length of the embryonic cardiac cell cycle and the timing of the cardiac differentiation program. Thus, these studies establish a role for TBX5 in regulating the progression of the cardiac cell cycle.

PubMed ID: 16728474
PMC ID: PMC1635805
Article link: Development.
Grant support: R01 HL075256 NHLBI NIH HHS , R21HL083965 NHLBI NIH HHS , T32HL69768 NHLBI NIH HHS , R01 HL075256-02 NHLBI NIH HHS , R01 HL075256-03 NHLBI NIH HHS , R21 HL083965 NHLBI NIH HHS , R21 HL083965-01A1 NHLBI NIH HHS , T32 HL069768 NHLBI NIH HHS

Genes referenced: act3 actc1 actl6a casp3 fbn1 fn1 mlc1 myh4 myh6 myod1 nkx2-5 tbx5 tpm1

Antibodies referenced: Tpm1 Ab1
Morpholinos referenced: tbx5 MO1 tbx5 MO2

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Agius, 2000, Pubmed, Xenbase [+]

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