Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-35868
FEBS J 2007 Mar 01;2746:1374-82. doi: 10.1111/j.1742-4658.2007.05696.x.
Show Gene links Show Anatomy links

What MAN1 does to the Smads. TGFbeta/BMP signaling and the nuclear envelope.

Bengtsson L .


???displayArticle.abstract???
The inner nuclear membrane protein MAN1 has been identified as an important factor in transforming growth factor beta/bone morphogenic protein (TGFbeta/BMP) signaling. Loss of MAN1 results in three autosomal dominant diseases in humans; all three characterized by increased bone density. Xenopus embryos lacking MAN1 develop severe morphological defects. Both in humans and in Xenopus embryos the defects originate from deregulation of TGFbeta/BMP signaling. Several independent studies have shown that MAN1 is antagonizing TGFbeta/BMP signaling through binding to regulatory Smads. Here, recent progress in understanding MAN1 functions is summarized and a model for MAN1-dependent regulation of TGFbeta/BMP signaling is proposed.

???displayArticle.pubmedLink??? 17489095
???displayArticle.link??? FEBS J


Species referenced: Xenopus
Genes referenced: lemd3 tgfb1