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Dev Biol June 15, 2007; 306 (2): 480-92.

Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings.

Furushima K , Yamamoto A , Nagano T , Shibata M , Miyachi H , Abe T , Ohshima N , Kiyonari H , Aizawa S .

In an effort to identify Otx2 targets in mouse anterior neuroectoderm we identified a gene, mShisa, which is homologous to xShisa1 that we previously reported as a head inducer in Xenopus. mShisa encodes an antagonist against both Wnt and Fgf signalings; it inhibits these signalings cell-autonomously as xShisa1 does. The mShisa expression is lost or greatly reduced in Otx2 mutant visceral endoderm, anterior mesendoderm and anterior neuroectoderm. However, mShisa mutants exhibited no defects in head development. Shisa is composed of five subfamilies, but normal head development in mShisa mutants is unlikely to be explained in terms of the compensation of mShisa deficiency by its paralogues or by known Wnt antagonists in anterior visceral endoderm and/or anterior mesendoderm.

PubMed ID: 17481602
Article link: Dev Biol

Genes referenced: calr fgf2 fzd8 lrp6 mix1 nodal3.1 nodal3.2 otx2 shisa1.1 shisa2 tbxt wnt3a wnt8a

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