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EMBO Rep February 1, 2007; 8 (2): 165-72.

MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly.

Franz C , Walczak R , Yavuz S , Santarella R , Gentzel M , Askjaer P , Galy V , Hetzer M , Mattaj IW , Antonin W .

The metazoan nuclear envelope (NE) breaks down and re-forms during each cell cycle. Nuclear pore complexes (NPCs), which allow nucleocytoplasmic transport during interphase, assemble into the re-forming NE at the end of mitosis. Using in vitro NE assembly, we show that the vertebrate homologue of MEL-28 (maternal effect lethal), a recently discovered NE component in Caenorhabditis elegans, functions in postmitotic NPC assembly. MEL-28 interacts with the Nup107-160 complex (Nup for nucleoporin), an important building block of the NPC, and is essential for the recruitment of the Nup107-160 complex to chromatin. We suggest that MEL-28 acts as a seeding point for NPC assembly.

PubMed ID: 17235358
PMC ID: PMC1796766
Article link: EMBO Rep

Genes referenced: ahctf1 mel nup107

Antonin, 2005, Pubmed, Xenbase [+]

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