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J Physiol
2007 Mar 15;579Pt 3:657-70. doi: 10.1113/jphysiol.2006.120733.
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Permeating protons contribute to tachyphylaxis of the acid-sensing ion channel (ASIC) 1a.
Chen X
,
Gründer S
.
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The homomeric acid-sensing ion channel 1a (ASIC1a) is a H+-activated ion channel with important physiological functions and pathophysiological impact in the central nervous system. Here we show that homomeric ASIC1a is distinguished from other ASICs by a reduced response to successive acid stimulations. Such a reduced response is called tachyphylaxis. We show that tachyphylaxis depends on H+ permeating through ASIC1a, that tachyphylaxis is attenuated by extracellular Ca2+, and that tachyphylaxis is probably linked to Ca2+ permeability of ASIC1a. Moreover, we provide evidence that tachyphylaxis is probably due to a long-lived inactive state of ASIC1a. A deeper understanding of ASIC1a tachyphylaxis may lead to pharmacological control of ASIC1a activity that could be of potential benefit for the treatment of stroke.
Alvarez de la Rosa,
Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system.
2002, Pubmed,
Xenbase
Alvarez de la Rosa,
Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system.
2002,
Pubmed
,
Xenbase
Askwith,
DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature.
2001,
Pubmed
,
Xenbase
Askwith,
Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons.
2004,
Pubmed
Babini,
Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acid-sensing ion channel 1 (ASIC1).
2002,
Pubmed
,
Xenbase
Baron,
ASIC-like, proton-activated currents in rat hippocampal neurons.
2002,
Pubmed
Bassilana,
The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties.
1997,
Pubmed
,
Xenbase
Benson,
Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons.
2002,
Pubmed
Brooker,
Calcium wave evoked by activation of endogenous or exogenously expressed receptors in Xenopus oocytes.
1990,
Pubmed
,
Xenbase
Bässler,
Molecular and functional characterization of acid-sensing ion channel (ASIC) 1b.
2001,
Pubmed
,
Xenbase
Canzoniero,
Recovery from NMDA-induced intracellular acidification is delayed and dependent on extracellular bicarbonate.
1996,
Pubmed
Chen,
Strong modulation by RFamide neuropeptides of the ASIC1b/3 heteromer in competition with extracellular calcium.
2006,
Pubmed
,
Xenbase
Coric,
The extracellular domain determines the kinetics of desensitization in acid-sensitive ion channel 1.
2003,
Pubmed
,
Xenbase
Coscoy,
The pre-transmembrane 1 domain of acid-sensing ion channels participates in the ion pore.
1999,
Pubmed
Coscoy,
The Phe-Met-Arg-Phe-amide-activated sodium channel is a tetramer.
1998,
Pubmed
,
Xenbase
Escoubas,
Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels.
2000,
Pubmed
,
Xenbase
Fakler,
Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels (ROMK) to intracellular pH.
1996,
Pubmed
,
Xenbase
Firsov,
The heterotetrameric architecture of the epithelial sodium channel (ENaC).
1998,
Pubmed
,
Xenbase
Gilbertson,
Proton currents through amiloride-sensitive Na+ channels in isolated hamster taste cells: enhancement by vasopressin and cAMP.
1993,
Pubmed
Gitterman,
Functional properties and pharmacological inhibition of ASIC channels in the human SJ-RH30 skeletal muscle cell line.
2005,
Pubmed
Hellwig,
TRPV1 acts as proton channel to induce acidification in nociceptive neurons.
2004,
Pubmed
Hiebsch,
Primaquine blocks transport by inhibiting the formation of functional transport vesicles. Studies in a cell-free assay of protein transport through the Golgi apparatus.
1991,
Pubmed
Irwin,
N-methyl-D-aspartate induces a rapid, reversible, and calcium-dependent intracellular acidosis in cultured fetal rat hippocampal neurons.
1994,
Pubmed
Kellenberger,
Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure.
2002,
Pubmed
Koplas,
The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons.
1997,
Pubmed
Neaga,
Extracellular trypsin increases ASIC1a selectivity for monovalent versus divalent cations.
2005,
Pubmed
Olson,
An acid sensing ion channel (ASIC) localizes to small primary afferent neurons in rats.
1998,
Pubmed
Paukert,
A family of acid-sensing ion channels from the zebrafish: widespread expression in the central nervous system suggests a conserved role in neuronal communication.
2004,
Pubmed
Paukert,
Identification of the Ca2+ blocking site of acid-sensing ion channel (ASIC) 1: implications for channel gating.
2004,
Pubmed
,
Xenbase
Poirot,
Distinct ASIC currents are expressed in rat putative nociceptors and are modulated by nerve injury.
2006,
Pubmed
Sontheimer,
Glial cells of the oligodendrocyte lineage express proton-activated Na+ channels.
1989,
Pubmed
Ugawa,
In situ hybridization evidence for the coexistence of ASIC and TRPV1 within rat single sensory neurons.
2005,
Pubmed
Ugawa,
Amiloride-insensitive currents of the acid-sensing ion channel-2a (ASIC2a)/ASIC2b heteromeric sour-taste receptor channel.
2003,
Pubmed
,
Xenbase
Volk,
Extracellular Na+ removal attenuates rundown of the epithelial Na+-channel (ENaC) by reducing the rate of channel retrieval.
2004,
Pubmed
,
Xenbase
Vukicevic,
Modulatory effects of acid-sensing ion channels on action potential generation in hippocampal neurons.
2004,
Pubmed
Waldmann,
The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans.
1996,
Pubmed
Waldmann,
A proton-gated cation channel involved in acid-sensing.
1997,
Pubmed
,
Xenbase
Waldmann,
Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons.
1997,
Pubmed
Wang,
Modulation of acid-sensing ion channel currents, acid-induced increase of intracellular Ca2+, and acidosis-mediated neuronal injury by intracellular pH.
2006,
Pubmed
Wang,
Glutamate-induced intracellular acidification of cultured hippocampal neurons demonstrates altered energy metabolism resulting from Ca2+ loads.
1994,
Pubmed
Wemmie,
The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory.
2002,
Pubmed
Wemmie,
Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning.
2003,
Pubmed
Wu,
Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord.
2004,
Pubmed
Xie,
DRASIC contributes to pH-gated currents in large dorsal root ganglion sensory neurons by forming heteromultimeric channels.
2002,
Pubmed
Xiong,
Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels.
2004,
Pubmed
Yermolaieva,
Extracellular acidosis increases neuronal cell calcium by activating acid-sensing ion channel 1a.
2004,
Pubmed
Zerangue,
A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels.
1999,
Pubmed
,
Xenbase
