Due to necessary maintenance, Xenbase will be unavailable from December 24-29, 2014. We apologize for the inconvenience.

Click on this message to dismiss it.
Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-36073
Neuroreport. July 2, 2007; 18 (10): 969-73.

The rat vanilloid receptor splice variant VR.5''sv blocks TRPV1 activation.

Eilers H , Lee SY , Hau CW , Logvinova A , Schumacher MA .


Abstract
The capsaicin receptor (VR1, TRPV1) is a ligand-gated ion channel predominantly expressed in peripheral nociceptors and activated by multiple noxious stimuli including products of inflammation. A 5''-splice variant (VR.5''sv) of TRPV1 has been previously isolated and found to be insensitive to noxious stimuli. We report in this study that coexpression of VR.5''sv with TRPV1 in Xenopus oocytes blocks TRPV1-mediated current responses. Oocytes expressing the inhibitory profile demonstrated colocalization of TRPV1 and VR.5''sv-associated immunostaining in the plasma membrane. TRPV1 protein expression was comparable in all groups. Evidence of endogenous VR.5''-splice variant-like-protein expression was detected in dorsal root ganglion. These results support the idea that coexpression of VR.5''sv or a similar variant could result in inhibitory modulation of TRPV1 activation.

PubMed ID: 17558279
Article link: Neuroreport.
Grant support: NS38737 NINDS NIH HHS

Genes referenced: trpv1
Antibodies referenced:
Morpholinos referenced:

My Xenbase: [ Log-in / Register ]
version: [3.3]


Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556