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XB-ART-36320
BMC Biol. July 25, 2007; 5 31.

Accelerated gene evolution and subfunctionalization in the pseudotetraploid frog Xenopus laevis.



Abstract
Ancient whole genome duplications have been implicated in the vertebrate and teleost radiations, and in the emergence of diverse angiosperm lineages, but the evolutionary response to such a perturbation is still poorly understood. The African clawed frog Xenopus laevis experienced a relatively recent tetraploidization ~40 million years ago. Analysis of the considerable amount of EST sequence available for this species together with the genome sequence of the related diploid Xenopus tropicalis provides a unique opportunity to study the genomic response to whole genome duplication. We identified 2218 gene triplets in which a single gene in X. tropicalis corresponds to precisely two co-orthologous genes in X. laevis--the largest such collection published from any duplication event in animals. Analysis of these triplets reveals accelerated evolution or relaxation of constraint in the peptides of the X. laevis pairs compared with the orthologous sequences in X. tropicalis and other vertebrates. In contrast, single-copy X. laevis genes do not show this acceleration. Duplicated genes can differ substantially in expression levels and patterns. We find no significant difference in gene content in the duplicated set, versus the single-copy set based on molecular and biological function ontologies. These results support a scenario in which duplicate genes are retained through a process of subfunctionalization and/or relaxation of constraint on both copies of an ancestral gene.

PubMed ID: 17651506
PMC ID: PMC1949811
Article link: BMC Biol.
Grant support: GM66684 NIGMS NIH HHS , K08-HD42550 NICHD NIH HHS , K08 HD042550 NICHD NIH HHS , R01 GM066684 NIGMS NIH HHS , GM66684 NIGMS NIH HHS , K08-HD42550 NICHD NIH HHS

Genes referenced: clock foxa1 skp1 sri


References:
, 2000, Pubmed[+]


Article Images: [+] show captions

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