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Dev Biol October 15, 2007; 310 (2): 402-15.

Regulation of the Xenopus Xsox17alpha(1) promoter by co-operating VegT and Sox17 sites.

Howard L , Rex M , Clements D , Woodland HR .

The gene encoding the Sox F-group transcription factor Xsox17alpha(1) is specifically expressed throughout the entire region of the Xenopus blastula fated to become endoderm, and is important in controlling endodermal development. Xsox17alpha(1) is a direct target of the maternal endodermal determinant VegT and of Sox17 itself. We have analysed the promoter of the Xenopus laevis Xsox17alpha(1) gene by transgenesis, and have identified two important control elements which reside about 9 kb upstream at the start of transcription. These elements individually drive transgenic endodermal expression in the blastula and gastrula. One contains functional, cooperating VegT and Sox-binding consensus sites. The Sox sites in this region are occupied in vivo. The other responds to TGF-beta signals like Activin or Nodals that act through Smad2/3. We propose that these two regions co-operate in regulating the early endodermal expression of the Xsox17alpha(1) gene.

PubMed ID: 17719026
PMC ID: PMC2098691
Article link: Dev Biol
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: acta4 actc1 actl6a smad2 sox17a sox17b.1 sox17b.2 tbx2 tgfb1 vegt

Article Images: [+] show captions
References [+] :
Afouda, GATA4, 5 and 6 mediate TGFbeta maintenance of endodermal gene expression in Xenopus embryos. 2005, Pubmed, Xenbase