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Development May 1, 2004; 131 (9): 2137-47.

Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex.

Mercurio S , Latinkic B , Itasaki N , Krumlauf R , Smith JC .

Connective-tissue growth factor (CTGF) is a member of the CCN family of secreted proteins. CCN family members contain four characteristic domains and exhibit multiple activities: they associate with the extracellular matrix, they can mediate cell adhesion, cell migration and chemotaxis, and they can modulate the activities of peptide growth factors. Many of the effects of CTGF are thought to be mediated by binding to integrins, whereas others may be because of its recently identified ability to interact with BMP4 and TGF beta. We demonstrate, using Xenopus embryos, that CTGF also regulates signalling through the Wnt pathway, in accord with its ability to bind to the Wnt co-receptor LDL receptor-related protein 6 (LRP6). This interaction is likely to occur through the C-terminal (CT) domain of CTGF, which is distinct from the BMP- and TGF beta-interacting domain. Our results define new activities of CTGF and add to the variety of routes through which cells regulate growth factor activity in development, disease and tissue homeostasis.

PubMed ID: 15105373
Article link: Development

Genes referenced: actl6a bmp4 ccn1 ccn2 dvl2 ins lrp6 mlc1 nodal3.1 nodal3.2 odc1 otx2 pax6 sia1 slit1 snai2 sox3 tgfb1 thbs1 tubb2b wnt8a
Morpholinos: ctgf MO1

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