Teper Y , Whyte D , Cahir E , Lester HA , Grady SR , Marks MJ , Cohen BN , Fonck C , McClure-Begley T , McIntosh JM , Labarca C , Lawrence A , Chen F , Gantois I , Davies PJ , Petrou S , Murphy M , Waddington J , Horne MK , Berkovic SF , Drago J .

DA003194 NIDA NIH HHS , DA012242 NIDA NIH HHS , DA015663 NIDA NIH HHS , MH53631 NIMH NIH HHS, NS046464 NINDS NIH HHS , NS43800 NINDS NIH HHS , R01 MH053631-11 NIMH NIH HHS, R01 MH053631-11S1 NIMH NIH HHS, R01 MH053631 NIMH NIH HHS, R01 DA003194 NIDA NIH HHS , R29 MH053631 NIMH NIH HHS, P30 DA015663 NIDA NIH HHS , R21 NS046464 NINDS NIH HHS , R01 NS043800 NINDS NIH HHS , R01 DA012242 NIDA NIH HHS

Aridon, Increased sensitivity of the neuronal nicotinic receptor alpha 2 subunit causes familial epilepsy with nocturnal wandering and ictal fear. 2006, Pubmed

Aridon, Increased sensitivity of the neuronal nicotinic receptor alpha 2 subunit causes familial epilepsy with nocturnal wandering and ictal fear. 2006, Pubmed
Bertrand, How mutations in the nAChRs can cause ADNFLE epilepsy. 2002, Pubmed , Xenbase
Bertrand, The CHRNB2 mutation I312M is associated with epilepsy and distinct memory deficits. 2005, Pubmed
Bertrand, Properties of neuronal nicotinic acetylcholine receptor mutants from humans suffering from autosomal dominant nocturnal frontal lobe epilepsy. 1998, Pubmed , Xenbase
Brodtkorb, Tobacco habits modulate autosomal dominant nocturnal frontal lobe epilepsy. 2006, Pubmed
Clarke, Chronic central nicotinic blockade after a single administration of the bisquaternary ganglion-blocking drug chlorisondamine. 1984, Pubmed
Collins, Sensitivity to nicotine and brain nicotinic receptors are altered by chronic nicotine and mecamylamine infusion. 1994, Pubmed
Combi, Autosomal dominant nocturnal frontal lobe epilepsy--a critical overview. 2004, Pubmed
Damaj, Pharmacological characterization of nicotine-induced seizures in mice. 1999, Pubmed
De Fusco, The nicotinic receptor beta 2 subunit is mutant in nocturnal frontal lobe epilepsy. 2000, Pubmed
Dobelis, GABAergic systems modulate nicotinic receptor-mediated seizures in mice. 2003, Pubmed
Drago, Targeted expression of a toxin gene to D1 dopamine receptor neurons by cre-mediated site-specific recombination. 1998, Pubmed
Du, Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder. 2005, Pubmed , Xenbase
Dávila-García, [125I]IPH, an epibatidine analog, binds with high affinity to neuronal nicotinic cholinergic receptors. 1997, Pubmed
Figl, Two mutations linked to nocturnal frontal lobe epilepsy cause use-dependent potentiation of the nicotinic ACh response. 1998, Pubmed , Xenbase
Fisher, Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). 2005, Pubmed
Fonck, Increased sensitivity to agonist-induced seizures, straub tail, and hippocampal theta rhythm in knock-in mice carrying hypersensitive alpha 4 nicotinic receptors. 2003, Pubmed
Fonck, Novel seizure phenotype and sleep disruptions in knock-in mice with hypersensitive alpha 4* nicotinic receptors. 2005, Pubmed , Xenbase
Franceschini, Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures. 2002, Pubmed
Gantois, Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior. 2007, Pubmed
Gerzanich, Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors. 1995, Pubmed , Xenbase
Giniatullin, Rapid relief of block by mecamylamine of neuronal nicotinic acetylcholine receptors of rat chromaffin cells in vitro: an electrophysiological and modeling study. 2000, Pubmed
Guerrini, Autosomal recessive rolandic epilepsy with paroxysmal exercise-induced dystonia and writer's cramp: delineation of the syndrome and gene mapping to chromosome 16p12-11.2. 1999, Pubmed
Guerrini, Idiopathic epilepsy and paroxysmal dyskinesia. 2001, Pubmed
Guerrini, Early-onset absence epilepsy and paroxysmal dyskinesia. 2002, Pubmed
Hayman, Autosomal dominant nocturnal frontal lobe epilepsy: demonstration of focal frontal onset and intrafamilial variation. 1997, Pubmed
Hirose, A novel mutation of CHRNA4 responsible for autosomal dominant nocturnal frontal lobe epilepsy. 1999, Pubmed
Kedmi, Mice lacking neuronal nicotinic acetylcholine receptor beta4-subunit and mice lacking both alpha5- and beta4-subunits are highly resistant to nicotine-induced seizures. 2004, Pubmed
Klaassen, Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy. 2006, Pubmed
Kuryatov, Nicotine acts as a pharmacological chaperone to up-regulate human alpha4beta2 acetylcholine receptors. 2005, Pubmed
Kuryatov, Mutation causing autosomal dominant nocturnal frontal lobe epilepsy alters Ca2+ permeability, conductance, and gating of human alpha4beta2 nicotinic acetylcholine receptors. 1997, Pubmed , Xenbase
Labarca, Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety. 2001, Pubmed
Lakso, Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. 1996, Pubmed
Leonard, Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptor. 1988, Pubmed , Xenbase
Lu, Pharmacological characterization of nicotinic receptor-stimulated GABA release from mouse brain synaptosomes. 1998, Pubmed
Marks, Two pharmacologically distinct components of nicotinic receptor-mediated rubidium efflux in mouse brain require the beta2 subunit. 1999, Pubmed
Marks, Deletion of the alpha7, beta2, or beta4 nicotinic receptor subunit genes identifies highly expressed subtypes with relatively low affinity for [3H]epibatidine. 2006, Pubmed
Marks, Gene targeting demonstrates that alpha4 nicotinic acetylcholine receptor subunits contribute to expression of diverse [3H]epibatidine binding sites and components of biphasic 86Rb+ efflux with high and low sensitivity to stimulation by acetylcholine. 2007, Pubmed
McColl, Electroencephalographic characterisation of pentylenetetrazole-induced seizures in mice lacking the alpha 4 subunit of the neuronal nicotinic receptor. 2003, Pubmed
Montagna, Nocturnal paroxysmal dystonia and nocturnal wandering. 1992, Pubmed
Oldani, Autosomal dominant nocturnal frontal lobe epilepsy. A video-polysomnographic and genetic appraisal of 40 patients and delineation of the epileptic syndrome. 1998, Pubmed
Papke, Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes. 2001, Pubmed , Xenbase
Phillips, CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy. 2001, Pubmed , Xenbase
Phillips, Autosomal dominant nocturnal frontal-lobe epilepsy: genetic heterogeneity and evidence for a second locus at 15q24. 1998, Pubmed
Plazzi, Epileptic nocturnal wanderings. 1995, Pubmed
Pradhan, [125I]Epibatidine-labelled nicotinic receptors in the extended striatum and cerebral cortex: lack of association with serotonergic afferents. 2002, Pubmed
Provini, Nocturnal frontal lobe epilepsy. A clinical and polygraphic overview of 100 consecutive cases. 1999, Pubmed
Provini, The wide clinical spectrum of nocturnal frontal lobe epilepsy. 2000, Pubmed
Rodrigues-Pinguet, Five ADNFLE mutations reduce the Ca2+ dependence of the mammalian alpha4beta2 acetylcholine response. 2003, Pubmed , Xenbase
Rodrigues-Pinguet, Mutations linked to autosomal dominant nocturnal frontal lobe epilepsy affect allosteric Ca2+ activation of the alpha 4 beta 2 nicotinic acetylcholine receptor. 2005, Pubmed , Xenbase
Ross, Phenotypic characterization of an alpha 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse. 2000, Pubmed
Salminen, Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice. 2004, Pubmed
Scheffer, Autosomal dominant nocturnal frontal lobe epilepsy. A distinctive clinical disorder. 1995, Pubmed
Steinlein, Independent occurrence of the CHRNA4 Ser248Phe mutation in a Norwegian family with nocturnal frontal lobe epilepsy. 2000, Pubmed
Steinlein, A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy. 1995, Pubmed
Steinlein, An insertion mutation of the CHRNA4 gene in a family with autosomal dominant nocturnal frontal lobe epilepsy. 1997, Pubmed
Weiland, An amino acid exchange in the second transmembrane segment of a neuronal nicotinic receptor causes partial epilepsy by altering its desensitization kinetics. 1996, Pubmed , Xenbase
Whiteaker, Pharmacological and null mutation approaches reveal nicotinic receptor diversity. 2000, Pubmed
Whiteaker, Identification of a novel nicotinic binding site in mouse brain using [(125)I]-epibatidine. 2000, Pubmed
Willoughby, Nicotine as an antiepileptic agent in ADNFLE: an N-of-one study. 2003, Pubmed
Wilson, Visualization of functionally activated circuitry in the brain. 2002, Pubmed
Yu, Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. 2006, Pubmed
Zucconi, Nocturnal paroxysmal arousals with motor behaviors during sleep: frontal lobe epilepsy or parasomnia? 1997, Pubmed