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Eur Biophys J July 1, 2007; 36 (6): 675-81.

Load-dependent release limits the processive stepping of the tetrameric Eg5 motor.

Korneev MJ , Lakämper S , Schmidt CF .

Tetrameric motor proteins of the Kinesin-5 family are essential for eukaryotic cell division. The microscopic mechanism by which Eg5, the vertebrate Kinesin-5, drives bipolar mitotic spindle formation remains unknown. Here we show in optical trapping experiments that full-length Eg5 moves processively and stepwise along microtubule bundles. Interestingly, the force produced by individual Eg5 motors typically reached only approximately 2 pN, one-third of the stall force of Kinesin-1. Eg5 typically detached from microtubules before stalling. This behavior may reflect a regulatory mechanism important for the role of Eg5 in the mitotic spindle.

PubMed ID: 17333163
PMC ID: PMC1914257
Article link: Eur Biophys J

Genes referenced: kif11 pdf

Article Images: [+] show captions
Allersma, 1998, Pubmed [+]

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