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XB-ART-37157
Dev Dyn. March 1, 2008; 237 (3): 768-79.

Wnt6 expression in epidermis and epithelial tissues during Xenopus organogenesis.

Lavery DL , Davenport IR , Turnbull YD , Wheeler GN , Hoppler S .


Abstract
Here, we report the localization within embryonic tissues of xWnt6 protein; together with the temporal and spatial expression of Xenopus laevis Wnt6 mRNA. Wnt6 expression in Xenopus embryos is low until later stages of neurulation, when it is predominantly found in the surface ectoderm. Wnt6 expression increases during early organogenesis in the epidermis overlaying several developing organs, including the eye, heart, and pronephros. At later stages of development, Wnt6 mRNA and protein generally localize in epithelial tissues and specifically within the epithelial tissues of these developing organs. Wnt6 localization correlates closely with sites of both epithelial to mesenchymal transformations and mesenchymal to epithelial transformations. Xenopus Wnt6 sequence and its expression pattern are highly conserved with other vertebrates. Xenopus embryos, therefore, provide an excellent model system for investigating the function of vertebrate Wnt6 in organ development and regulation of tissue architecture.

PubMed ID: 18224714
Article link: Dev Dyn.
Grant support: Biotechnology and Biological Sciences Research CouncilWellcome Trust

Genes referenced: hist1h4d mapk1 myc rho tbx2 tnnt2 wnt4 wnt6

Antibodies referenced: Tnnt2 Ab1


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