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XB-ART-37217
Dev Biol March 15, 2008; 315 (2): 579-92.

The POU homeobox protein Oct-1 regulates radial glia formation downstream of Notch signaling.

Kiyota T , Kato A , Altmann CR , Kato Y .


Abstract
Radial glia cells function as guide cells for neuronal migration and a source of neural progenitor cells, and play a crucial role for the development of the central nervous system. To date, several signals have been demonstrated to promote the formation of radial glia cells and Notch signaling is one such signal. However, the mechanism of the signaling hierarchy of radial glia developmental cascade promoted by Notch signaling still remains incomplete. Here we show that Notch signaling promotes Xenopus radial glia formation and that the Notch activation is sufficient for radial glia formation prior to neural tube closure. Moreover, we have identified Oct-1 (POU2f1), a POU transcription factor, as a downstream target of Notch signaling by microarray based screen. We demonstrate that the expression of Oct-1 in the brain is regulated by Notch signaling and that Oct-1 is sufficient and necessary for radial glia formation. Together, Oct-1 is a downstream effector of Notch signaling during radial glia formation.

PubMed ID: 18241856
Article link: Dev Biol

Genes referenced: dll1 gal.2 notch1 pou2f1 vim
Morpholinos: pou2f1 MO1

GEO Series:
   GSE5564: NCBI


Article Images: [+] show captions


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