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XB-ART-37353
Cell. February 8, 2008; 132 (3): 434-48.

A combinatorial code for CPE-mediated translational control.

Piqué M , López JM , Foissac S , Guigó R , Méndez R .


Abstract
Cytoplasmic polyadenylation plays a key role in the translational control of mRNAs driving biological processes such as gametogenesis, cell-cycle progression, and synaptic plasticity. What determines the distinct time of polyadenylation and extent of translational control of a given mRNA, however, is poorly understood. The polyadenylation-regulated translation is controlled by the cytoplasmic polyadenylation element (CPE) and its binding protein, CPEB, which can assemble both translational repression or activation complexes. Using a combination of mutagenesis and experimental validation of genome-wide computational predictions, we show that the number and relative position of two elements, the CPE and the Pumilio-binding element, with respect to the polyadenylation signal define a combinatorial code that determines whether an mRNA will be translationally repressed by CPEB, as well as the extent and time of cytoplasmic polyadenylation-dependent translational activation.

PubMed ID: 18267074
Article link: Cell.

Genes referenced: cpeb1 pum1
Antibodies referenced:
Morpholinos referenced:

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