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XB-ART-37368
Dev Cell March 1, 2008; 14 (3): 424-36.

Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus.

Langer EM , Feng Y , Zhaoyuan H , Rauscher FJ , Kroll KL , Longmore GD .


Abstract
Snail family transcriptional repressors regulate epithelial mesenchymal transitions during physiological and pathological processes. A conserved SNAG repression domain present in all vertebrate Snail proteins is necessary for repressor complex assembly. Here, we identify the Ajuba family of LIM proteins as functional corepressors of the Snail family via an interaction with the SNAG domain. Ajuba LIM proteins interact with Snail in the nucleus on endogenous E-cadherin promoters and contribute to Snail-dependent repression of E-cadherin. Using Xenopus neural crest as a model of in vivo Snail- or Slug-induced EMT, we demonstrate that Ajuba LIM proteins contribute to neural crest development as Snail/Slug corepressors and are required for in vivo Snail/Slug function. Because Ajuba LIM proteins are also components of adherens junctions and contribute to their assembly or stability, their functional interaction with Snail proteins in the nucleus suggests that Ajuba LIM proteins are important regulators of epithelia dynamics communicating surface events with nuclear responses.

PubMed ID: 18331720
PMC ID: PMC2279146
Article link: Dev Cell
Grant support: [+]
Genes referenced: cdh1 gal.2 itk krt12.4 limd1 snai1 snai2 sox2 twist1 wtip
Morpholinos: limd1 MO1 snai2 MO1 wtip MO1


Article Images: [+] show captions
References [+] :
Aybar, Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest. 2002, Pubmed, Xenbase


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