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XB-ART-3750
Curr Biol 2004 Apr 06;147:R277-8. doi: 10.1016/j.cub.2004.03.023.
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Signal transduction: implications for Ras-dependent ERK signaling.

Ory S , Morrison DK .


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Ras interacts with numerous downstream effectors to transmit a diverse array of cellular signals. A new study shows that a protein known as Impedes Mitogenic signal Propagation, IMP, is an E3 ubiquitin ligase that binds Ras and modulates MAP kinase signaling by regulating the scaffolding activity of KSR.

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Species referenced: Xenopus
Genes referenced: brap igf2bp3 impdh1 mapk1