Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
J Biomed Biotechnol. January 1, 2007; 2007 76514.

Imaging GABAc receptors with ligand-conjugated quantum dots.

Tomlinson ID , Gussin HA , Little DM , Warnement MR , Qian H , Pepperberg DR , Rosenthal SJ .

We report a methodology for labeling the GABAc receptor on the surface membrane of intact cells. This work builds upon our earlier work with serotonin-conjugated quantum dots and our studies with PEGylated quantum dots to reduce nonspecific binding. In the current approach, a PEGylated derivative of muscimol was synthesized and attached via an amide linkage to quantum dots coated in an amphiphilic polymer derivative of a modified polyacrylamide. These conjugates were used to image GABA(C) receptors heterologously expressed in Xenopus laevis oocytes.

PubMed ID: 18437227
PMC ID: PMC2323551
Article link: J Biomed Biotechnol.

Genes referenced: boc dcc gabarap nhs slc6a4 tbx2

External Resources:
Article Images: [+] show captions

Agostiano, 2000, Pubmed[+]

Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.9.0
Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556