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J Biomed Biotechnol. January 1, 2007; 2007 76514.

Imaging GABAc receptors with ligand-conjugated quantum dots.

Tomlinson ID , Gussin HA , Little DM , Warnement MR , Qian H , Pepperberg DR , Rosenthal SJ .

We report a methodology for labeling the GABAc receptor on the surface membrane of intact cells. This work builds upon our earlier work with serotonin-conjugated quantum dots and our studies with PEGylated quantum dots to reduce nonspecific binding. In the current approach, a PEGylated derivative of muscimol was synthesized and attached via an amide linkage to quantum dots coated in an amphiphilic polymer derivative of a modified polyacrylamide. These conjugates were used to image GABA(C) receptors heterologously expressed in Xenopus laevis oocytes.

PubMed ID: 18437227
PMC ID: PMC2323551
Article link: J Biomed Biotechnol.

Genes referenced: boc dcc gabarap nhs slc6a4 tbx2

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