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XB-ART-37682
PLoS One April 30, 2008; 3 (4): e2029.

The mych gene is required for neural crest survival during zebrafish development.

Hong SK , Tsang M , Dawid IB .


Abstract
Among Myc family genes, c-Myc is known to have a role in neural crest specification in Xenopus and in craniofacial development in the mouse. There is no information on the function of other Myc genes in neural crest development, or about any developmental role of zebrafish Myc genes. We isolated the zebrafish mych (myc homologue) gene. Knockdown of mych leads to severe defects in craniofacial development and in certain other tissues including the eye. These phenotypes appear to be caused by cell death in the neural crest and in the eye field in the anterior brain. Mych is a novel factor required for neural crest cell survival in zebrafish.

PubMed ID: 18446220
PMC ID: PMC2323570
Article link: PLoS One
Grant support: [+]

Species referenced: Xenopus
Genes referenced: barhl2 elavl3 fli1 foxd3 gsc hand2 mab21l2 myc nusap1 pcdh8 pcdh8.2 sox10 tbx1 tbxt tnc


Article Images: [+] show captions
References [+] :
Akimenko, Combinatorial expression of three zebrafish genes related to distal-less: part of a homeobox gene code for the head. 1994, Pubmed