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XB-ART-37711
Toxicon June 15, 2008; 51 (8): 1424-30.

OdK2, a Kv1.3 channel-selective toxin from the venom of the Iranian scorpion Odonthobuthus doriae.

Abdel-Mottaleb Y , Vandendriessche T , Clynen E , Landuyt B , Jalali A , Vatanpour H , Schoofs L , Tytgat J .


Abstract
The first Kv1.3 channel-selective toxin from the venom of the Iranian scorpion Odonthobuthus doriae (OdK2) was purified, sequenced and characterized physiologically. OdK2 consists of 38 amino acids, including six conserved cysteine and a C-terminal lysine residue, as revealed by the unique use of a quadrupole ion cyclotron resonance Fourier-transform mass spectrometer. Based on multiple sequence alignments, OdK2 was classified as alpha-KTX3.11. The pharmacological effects of OdK2 were studied on a panel of eight different cloned K(+) channels (vertebrate Kv1.1-Kv1.6, Shaker IR and hERG) expressed in Xenopus laevis oocytes. Interestingly, OdK2 selectively inhibits the currents through Kv1.3 channels with an IC50 value of 7.2+/-2.7nM.

PubMed ID: 18471844
Article link: Toxicon


Species referenced: Xenopus
Genes referenced: kcna1 kcna3 kcna6 kcnh2