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Cell May 30, 2008; 133 (5): 767-9.

p53 regulation orchestrates the TGF-beta response.

Among its multiple functions, p53 is a critical regulator of TGF-beta responses. Sasai et al. (2008) now identify a new p53 inhibitory protein, XFDL156. During embryonic development, this factor is expressed in the ectoderm germ layer and maintains the pluripotency of ectodermal cells by inhibiting TGF-beta target genes that promote mesoderm specification.

PubMed ID: 18510920
Article link: Cell

Genes referenced: fgf2 smad1 smad2 tbx2 tgfb1 tp53 trim33 znf585b

Sasai, 2008, Pubmed, Xenbase

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