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XB-ART-38021
Dev Biol September 1, 2008; 321 (1): 150-61.

DM-GRASP/ALCAM/CD166 is required for cardiac morphogenesis and maintenance of cardiac identity in first heart field derived cells.

Gessert S , Maurus D , Brade T , Walther P , Pandur P , Kühl M .


Abstract
Vertebrate heart development requires specification of cardiac precursor cells, migration of cardiac progenitors as well as coordinated cell movements during looping and septation. DM-GRASP/ALCAM/CD166 is a member of the neuronal immunoglobulin domain superfamily of cell adhesion molecules and was recently suggested to be a target gene of non-canonical Wnt signalling. Loss of DM-GRASP function did not affect specification of cardiac progenitor cells. Later during development, expression of cardiac marker genes in the first heart field of Xenopus laevis such as Tbx20 and TnIc was reduced, whereas expression of the second heart field marker genes Isl-1 and BMP-4 was unaffected. Furthermore, loss of DM-GRASP function resulted in defective cell adhesion and cardiac morphogenesis. Additionally, expression of DM-GRASP can rescue the phenotype that results from the loss of non-canonical Wnt11-R signalling suggesting that DM-GRASP and non-canonical Wnt signalling are functionally coupled during cardiac development.

PubMed ID: 18598690
Article link: Dev Biol

Genes referenced: actc1 alcam bmp4 cactin isl1 myh6 nkx2-5 shf tbx20 tnni3 wnt11 wnt11b zmym3
Morpholinos: alcam MO1 alcam MO2 alcam MO3 isl1 MO1 krt2l MO1 tbx20 MO1 tbx20 MO2 zmym3 MO1


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