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XB-ART-38063
Dev Biol August 15, 2008; 320 (2): 436-45.

Extracellular regulation of developmental cell signaling by XtSulf1.

Freeman SD , Moore WM , Guiral EC , Holme AD , Turnbull JE , Pownall ME .


Abstract
Heparan sulfate proteoglycans (HSPGs) are synthesised and modified in the Golgi before they are presented at the cell surface. Modifications include the addition of sulfate groups at specific positions on sugar residues along the heparan sulfate (HS) chain which results in a structural heterogeneity that underpins the ability of HSPGs to bind with high affinity to many different proteins, including growth factors and their receptors. Sulf1 codes for a 6-0-endosulfatase that is present and active extracellularly, providing a further mechanism to generate structural diversity through the post-synthetic remodelling of HS. Here we use Xenopus embryos to demonstrate in vivo that Xtsulf1 plays an important role in modulating cell signaling during development. We show that while XtSulf1 can enhance the axis-inducing activity of Wnt11, XtSulf1 acts during embryogenesis to restrict BMP and FGF signaling.

PubMed ID: 18617162
Article link: Dev Biol
Grant support: [+]
Genes referenced: bmp4 bmpr1a cdx4 chrd.1 fgf4 lrp6 mapk1 mespa msx1 myc myod1 ncam1 nodal3.1 nodal3.2 otx2 pax6 ripply2.2 sulf1 sulf2 szl tbxt wnt11
Morpholinos: sulf1 MO1 sulf1 MO2


Article Images: [+] show captions


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