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XB-ART-38095
Dev Dyn August 1, 2008; 237 (8): 2147-57.

Xenopus zinc finger transcription factor IA1 (Insm1) expression marks anteroventral noradrenergic neuron progenitors in Xenopus embryos.

Parlier D , Ariza A , Christulia F , Genco F , Vanhomwegen J , Kricha S , Souopgui J , Bellefroid EJ .


Abstract
The evolutionarily conserved IA1 (Insm1) gene is strongly expressed in the developing nervous system. Here, we show that IA1 is expressed during Xenopus laevis embryogenesis in neural plate primary neurons as well as in a population of uncharacterized anteroventral cells that form in front of the cement gland and that we identified as noradrenergic neurons. We also show that the formation of those anteroventral cells is dependent on BMPs and inhibited by Notch and that it is regulated by the transcription factors Xash1, Phox2, and Hand2. Finally, we provide functional evidence suggesting that IA1 may also play a role in their formation. Together, our results reveal that IA1 constitutes a novel player downstream of Xash1 in the formation of a previously unidentified population of Xenopus noradrenergic primary neurons.

PubMed ID: 18627098
Article link: Dev Dyn

Genes referenced: ank1 ankh ascl1 b3gat1l bmp4 celf3 dll1 dpysl3 elavl3 hand2 insm1 krt12.4 muc2 muc2l myt1 neurog1 nkx2-5 notch1 phox2a phox2b th tlx1 tlx3 vgll4
Morpholinos: ascl1 MO1 ascl1 MO2 hand2 MO1 insm1 MO2 insm1 MO3 neurog2 MO1 phox2a MO1


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