Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-38137
Dev Dyn August 1, 2008; 237 (8): 2177-86.

Bmp signaling is necessary and sufficient for ventrolateral endoderm specification in Xenopus.

Wills A , Dickinson K , Khokha M , Baker JC .


Abstract
Here we show that Bmp signaling is necessary and sufficient for the specification of ventral endoderm in Xenopus embryos. Overexpression of Bmp4 in ectoderm induces markers of endoderm, including Sox17beta, Mixer, and VegT, but cannot induce the expression of the dorsoanterior markers, Xhex and Cerberus. Furthermore, knockdown approaches using overexpression of Bmp antagonists and morpholinos designed against Bmp4, Bmp2, and Bmp7 demonstrate that Bmp signaling is critical for ventral, but not dorsoanterior endoderm formation. This activity is not simply a result of embryonic dorsalization as markers for dorsal endoderm are not expanded. We further show that endodermal cells of either ventral or dorsal character do not form when both Wnt and Bmp signals are abolished. Overall, this report strongly suggests that Bmp plays an essential role in ventral endoderm specification.

PubMed ID: 18651654
PMC ID: PMC4497515
Article link: Dev Dyn
Grant support: [+]
Genes referenced: bmp2 bmp4 bmp7.1 bmp7.2 bmpr1a cer1 chrd.1 gal.2 gdf3 hhex mixer myf5 nog sox17a sox17b.1 sox17b.2 tbxt vegt ventx2.2


Article Images: [+] show captions
References:
Agius, 2000, Pubmed, Xenbase [+]


Xenbase: The Xenopus laevis and X. tropicalis resource.
Version: 4.11.2


Major funding for Xenbase is provided by grant P41 HD064556