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Nat Neurosci June 1, 2008; 11 (6): 631-3.

Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri.

Zhang F , Prigge M , Beyrière F , Tsunoda SP , Mattis J , Yizhar O , Hegemann P , Deisseroth K .

The introduction of two microbial opsin-based tools, channelrhodopsin-2 (ChR2) and halorhodopsin (NpHR), to neuroscience has generated interest in fast, multimodal, cell type-specific neural circuit control. Here we describe a cation-conducting channelrhodopsin (VChR1) from Volvox carteri that can drive spiking at 589 nm, with excitation maximum red-shifted approximately 70 nm compared with ChR2. These results demonstrate fast photostimulation with yellow light, thereby defining a functionally distinct third category of microbial rhodopsin proteins.

PubMed ID: 18432196
PMC ID: PMC2692303
Article link: Nat Neurosci
Grant support: [+]
Genes referenced: rho

References [+] :
Adamantidis, Neural substrates of awakening probed with optogenetic control of hypocretin neurons. 2007, Pubmed

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