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Int J Dev Biol January 1, 2008; 52 (4): 371-5.

Concentrations of TATA box-binding protein (TBP)-type genes affect chordamesodermal gene expression.

The TATA box-binding protein (TBP) is an essential component of transcription initiation complexes of all three eukaryotic RNA polymerases. Recent knockdown studies revealed that basic transcription factors are essential not only for gene transcription but also for regulating specific gene expression. However, the mechanism of and the effect by regulation of TBP expression are unknown during early embryogenesis. Here we show that the alteration of concentration of each TBP-type gene affected mutually one another''s expression, suggesting that an optimal ratio of concentrations of TBP-type genes induce expression of specific genes.

PubMed ID: 18415937
Article link: Int J Dev Biol
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: chrd.1 ctse foxa4 gsc not tbp tbpl1 tbpl2 tbxt
Morpholinos: tbp MO1 tbpl1 MO1 tbpl2 MO1

Article Images: [+] show captions