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Cell September 5, 2008; 134 (5): 718-9.

A protein scaffold plays matchmaker for chordin.

In this issue, Inomata et al. (2008) report that the scaffold protein Olfactomedin 1 (ONT1) recruits the Tolloid proteases to their substrate Chordin, an antagonist of bone morphogenetic proteins (BMPs), during development of the frog embryo. Consequently, ONT1 expression in the organizer of the late gastrula stabilizes the gradient of BMP signaling that is essential for dorsoventral patterning.

PubMed ID: 18775302
Article link: Cell

Genes referenced: bmp1 chrd.1 olfml3 tbx2 twsg1

Article Images: [+] show captions
References :
Inomata, Robust stability of the embryonic axial pattern requires a secreted scaffold for chordin degradation. 2008, Pubmed, Xenbase

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