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XB-ART-38663
Nat Cell Biol January 1, 2009; 11 (1): 46-55.

Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction.

Kobayashi K , Luo M , Zhang Y , Wilkes DC , Ge G , Grieskamp T , Yamada C , Liu TC , Huang G , Basson CT , Kispert A , Greenspan DS , Sato TN .


Abstract
Secreted Frizzled-related proteins (sFRPs) have emerged as key regulators of a wide range of developmental and disease processes. Most of the known functions of mammalian sFRPs have been attributed to their ability to antagonize Wnt signalling. Recently however, Xenopus laevis and zebrafish sFRP, Sizzled, was shown to function as an antagonist of Chordin processing by Tolloid-like metalloproteinases. This has led to the proposal that sFRPs may function as evolutionarily conserved antagonists of chordinase activities of this class of proteinases. In contrast to this proposal, we show here that the mammalian sFRP, sFRP2, does not affect Chordin processing, but instead, can serve as a direct enhancer of procollagen C proteinase activity of Tolloid-like metalloproteinases. We also show that the level of fibrosis, in which procollagen processing by Tolloid-like proteinases has a rate-limiting role, is markedly reduced in Sfrp2-null mice subjected to myocardial infarction. Importantly, this reduced level of fibrosis is accompanied by significantly improved cardiac function. This study thus uncovers a function for sFRP2 and a potential therapeutic application for sFRP2 antagonism in controlling fibrosis in the infarcted heart.

PubMed ID: 19079247
PMC ID: PMC2722759
Article link: Nat Cell Biol
Grant support: [+]
Genes referenced: bmp1 chrd.1 efs egf gnl3 ntsr1 pc.1 sfrp2 szl

Disease Ontology terms: myocardial infarction

Article Images: [+] show captions
References [+] :
Barandon, Reduction of infarct size and prevention of cardiac rupture in transgenic mice overexpressing FrzA. 2003, Pubmed


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