Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Nature
2008 Nov 13;4567219:195-201. doi: 10.1038/nature07569.
Show Gene links
Show Anatomy links
Illumination controls differentiation of dopamine neurons regulating behaviour.
Dulcis D
,
Spitzer NC
.
???displayArticle.abstract???
Specification of the appropriate neurotransmitter is a crucial step in neuronal differentiation because it enables signalling among populations of neurons. Experimental manipulations demonstrate that both autonomous and activity-dependent genetic programs contribute to this process during development, but whether natural environmental stimuli specify transmitter expression in a neuronal population is unknown. We investigated neurons of the ventralsuprachiasmatic nucleus that regulate neuroendocrine pituitary function in response to light in teleosts, amphibia and primates. Here we show that altering light exposure, which changes the sensory input to the circuit controlling adaptation of skin pigmentation to background, changes the number of neurons expressing dopamine in larvae of the amphibian Xenopus laevis in a circuit-specific and activity-dependent manner. Neurons newly expressing dopamine then regulate changes in camouflage colouration in response to illumination. Thus, physiological activity alters the numbers of behaviourally relevant amine-transmitter-expressing neurons in the brain at postembryonic stages of development. The results may be pertinent to changes in cognitive states that are regulated by biogenic amines.
Abizaid,
Direct visual and circadian pathways target neuroendocrine cells in primates.
2004, Pubmed
Abizaid,
Direct visual and circadian pathways target neuroendocrine cells in primates.
2004,
Pubmed
Akopian,
D2 dopamine receptor-mediated inhibition of a hyperpolarization-activated current in rod photoreceptors.
1996,
Pubmed
,
Xenbase
Baquet,
Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta.
2005,
Pubmed
Berghs,
The secretory granule and pro-opiomelanocortin processing in Xenopus melanotrope cells during background adaptation.
1997,
Pubmed
,
Xenbase
Borodinsky,
Activity-dependent homeostatic specification of transmitter expression in embryonic neurons.
2004,
Pubmed
,
Xenbase
Borodinsky,
Activity-dependent neurotransmitter-receptor matching at the neuromuscular junction.
2007,
Pubmed
,
Xenbase
Brosenitsch,
Expression of Phox2 transcription factors and induction of the dopaminergic phenotype in primary sensory neurons.
2002,
Pubmed
Brunelli,
Glutamatergic reinnervation through peripheral nerve graft dictates assembly of glutamatergic synapses at rat skeletal muscle.
2005,
Pubmed
Catalano,
Activity-dependent regulation of NMDAR1 immunoreactivity in the developing visual cortex.
1997,
Pubmed
El Majdoubi,
Activity-dependent morphological synaptic plasticity in an adult neurosecretory system: magnocellular oxytocin neurons of the hypothalamus.
2000,
Pubmed
Fletcher,
Absence epilepsy in tottering mutant mice is associated with calcium channel defects.
1996,
Pubmed
Froemke,
A synaptic memory trace for cortical receptive field plasticity.
2007,
Pubmed
Goridis,
Specification of catecholaminergic and serotonergic neurons.
2002,
Pubmed
Green,
Ontogeny of circadian and light regulation of melatonin release in Xenopus laevis embryos.
1999,
Pubmed
,
Xenbase
Gómez-Lira,
Programmed and induced phenotype of the hippocampal granule cells.
2005,
Pubmed
Hess,
Tottering and leaner mutations perturb transient developmental expression of tyrosine hydroxylase in embryologically distinct Purkinje cells.
1991,
Pubmed
Jenks,
Plasticity in the melanotrope neuroendocrine interface of Xenopus laevis.
2007,
Pubmed
,
Xenbase
Kidd,
Developmental and activity-dependent regulation of kainate receptors at thalamocortical synapses.
1999,
Pubmed
Kim,
A MicroRNA feedback circuit in midbrain dopamine neurons.
2007,
Pubmed
Kolk,
Physiological control of Xunc18 expression in neuroendocrine melanotrope cells of Xenopus laevis.
2001,
Pubmed
,
Xenbase
Kramer,
Dynamics and plasticity of peptidergic control centres in the retino-brain-pituitary system of Xenopus laevis.
2001,
Pubmed
,
Xenbase
Lam,
Zebrafish embryos are susceptible to the dopaminergic neurotoxin MPTP.
2005,
Pubmed
Lam,
Pathophysiology of seasonal affective disorder: a review.
2000,
Pubmed
Lam,
Effects of alpha-methyl-para-tyrosine-induced catecholamine depletion in patients with seasonal affective disorder in summer remission.
2001,
Pubmed
Li,
Effects of dopamine depletion on visual sensitivity of zebrafish.
2000,
Pubmed
Logan,
Regulation of pigmentation in zebrafish melanophores.
2006,
Pubmed
Mastick,
Pax6 regulates the identity of embryonic diencephalic neurons.
2001,
Pubmed
McFarlane,
FGF signaling and target recognition in the developing Xenopus visual system.
1995,
Pubmed
,
Xenbase
McKinley,
Neuroprotection of MPTP-induced toxicity in zebrafish dopaminergic neurons.
2005,
Pubmed
Michel,
Excitatory mechanisms in the suprachiasmatic nucleus: the role of AMPA/KA glutamate receptors.
2002,
Pubmed
Mueller,
Activity-dependent modulation of neurotransmitter innervation to vasopressin neurons of the supraoptic nucleus.
2005,
Pubmed
Obernosterer,
Locked nucleic acid-based in situ detection of microRNAs in mouse tissue sections.
2007,
Pubmed
Olive,
Expression of a glycosyl phosphatidylinositol-anchored adhesion molecule, the glycoprotein F3, in the adult rat hypothalamo-neurohypophysial system.
1995,
Pubmed
Shi,
Activity-dependent induction of tonic calcineurin activity mediates a rapid developmental downregulation of NMDA receptor currents.
2000,
Pubmed
Thor,
Neuroscience: Light moulds plastic brains.
2008,
Pubmed
,
Xenbase
Tonosaki,
D2-like dopamine receptor mediates dopaminergic or gamma-aminobutyric acidergic inhibition of melanotropin-releasing hormone release from the pars intermedia in frogs (Rana nigromaculata).
1995,
Pubmed
Tuinhof,
Involvement of retinohypothalamic input, suprachiasmatic nucleus, magnocellular nucleus and locus coeruleus in control of melanotrope cells of Xenopus laevis: a retrograde and anterograde tracing study.
1994,
Pubmed
,
Xenbase
Ubink,
Identification of suprachiasmatic melanotrope-inhibiting neurons in Xenopus laevis: a confocal laser-scanning microscopy study.
1998,
Pubmed
,
Xenbase
Vazquez-Martinez,
Melanotrope cell plasticity: a key mechanism for the physiological adaptation to background color changes.
2001,
Pubmed
Walicke,
On the role of Ca2+ in the transmitter choice made by cultured sympathetic neurons.
1981,
Pubmed
Wang,
Endogenous activation of dopamine D2 receptors regulates dopamine release in the fish retina.
1997,
Pubmed
Wullimann,
Detailed immunohistology of Pax6 protein and tyrosine hydroxylase in the early zebrafish brain suggests role of Pax6 gene in development of dopaminergic diencephalic neurons.
2001,
Pubmed
Zhang,
Calcium channel kinetics of melanotrope cells in Xenopus laevis depend on environmental stimulation.
2008,
Pubmed
,
Xenbase
