San-Cristobal P , Ponce-Coria J , Vázquez N , Bobadilla NA , Gamba G .

DK-64635 NIDDK NIH HHS

Adragna, Regulation of K-Cl cotransport: from function to genes. 2004, Pubmed

Adragna, Regulation of K-Cl cotransport: from function to genes. 2004, Pubmed
Cai, WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells. 2006, Pubmed , Xenbase
Delaloy, Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform. 2003, Pubmed
Flatman, Regulation of Na-K-2Cl cotransport by phosphorylation and protein-protein interactions. 2002, Pubmed
Flatman, Cotransporters, WNKs and hypertension: important leads from the study of monogenetic disorders of blood pressure regulation. 2007, Pubmed
Gagnon, Volume sensitivity of cation-Cl- cotransporters is modulated by the interaction of two kinases: Ste20-related proline-alanine-rich kinase and WNK4. 2006, Pubmed , Xenbase
Gamba, Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney. 1994, Pubmed , Xenbase
Gamba, Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters. 2005, Pubmed
Garzón-Muvdi, WNK4 kinase is a negative regulator of K+-Cl- cotransporters. 2007, Pubmed , Xenbase
Golbang, Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved. 2006, Pubmed , Xenbase
Hebert, Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. 2004, Pubmed
Kahle, WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability. 2005, Pubmed , Xenbase
Kahle, WNK protein kinases modulate cellular Cl- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransporters. 2006, Pubmed
Lalioti, Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule. 2006, Pubmed
Lauf, K-Cl cotransport: properties and molecular mechanism. 2000, Pubmed , Xenbase
Lenertz, Properties of WNK1 and implications for other family members. 2005, Pubmed
Mayan, Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density. 2002, Pubmed
McCormick, WNK kinases and renal sodium transport in health and disease: an integrated view. 2008, Pubmed
Moreno, Affinity-defining domains in the Na-Cl cotransporter: a different location for Cl- and thiazide binding. 2006, Pubmed , Xenbase
Moriguchi, WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. 2005, Pubmed
O'Reilly, WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain. 2003, Pubmed
O'Reilly, Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo. 2006, Pubmed , Xenbase
Pacheco-Alvarez, The Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion. 2006, Pubmed , Xenbase
Peng, WNK4-mediated regulation of renal ion transport proteins. 2007, Pubmed , Xenbase
Ponce-Coria, Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases. 2008, Pubmed , Xenbase
Rinehart, WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. 2005, Pubmed , Xenbase
Simon, Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter. 1996, Pubmed
Song, Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter. 2002, Pubmed , Xenbase
Subramanya, Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform. 2006, Pubmed , Xenbase
Vitari, The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. 2005, Pubmed
Wang, Domains of WNK1 kinase in the regulation of ROMK1. 2008, Pubmed
Wilson, Human hypertension caused by mutations in WNK kinases. 2001, Pubmed
Wilson, Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. 2003, Pubmed , Xenbase
Xu, WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. 2000, Pubmed
Xu, Regulation of WNK1 by an autoinhibitory domain and autophosphorylation. 2002, Pubmed
Yang, Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. 2007, Pubmed
Yang, The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex. 2007, Pubmed , Xenbase
Yang, WNK kinases regulate thiazide-sensitive Na-Cl cotransport. 2003, Pubmed , Xenbase
Yang, Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport. 2005, Pubmed
de Los Heros, WNK3 bypasses the tonicity requirement for K-Cl cotransporter activation via a phosphatase-dependent pathway. 2006, Pubmed , Xenbase