Panaghie G , Purtell K , Tai KK , Abbott GW .

R01 HL079275 NHLBI NIH HHS

Ahern, A cation-pi interaction between extracellular TEA and an aromatic residue in potassium channels. 2006, Pubmed

Ahern, A cation-pi interaction between extracellular TEA and an aromatic residue in potassium channels. 2006, Pubmed
Andalib, The external TEA binding site and C-type inactivation in voltage-gated potassium channels. 2004, Pubmed
Barhanin, K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current. 1996, Pubmed , Xenbase
Baukrowitz, Modulation of K+ current by frequency and external [K+]: a tale of two inactivation mechanisms. 1995, Pubmed
Bezanilla, Negative conductance caused by entry of sodium and cesium ions into the potassium channels of squid axons. 1972, Pubmed
Castle, 4-Aminopyridine binding and slow inactivation are mutually exclusive in rat Kv1.1 and Shaker potassium channels. 1994, Pubmed , Xenbase
Dedek, Colocalization of KCNQ1/KCNE channel subunits in the mouse gastrointestinal tract. 2001, Pubmed
Demo, The inactivation gate of the Shaker K+ channel behaves like an open-channel blocker. 1991, Pubmed
Ding, Investigating the putative glycine hinge in Shaker potassium channel. 2005, Pubmed , Xenbase
Eghbali, External pore collapse as an inactivation mechanism for Kv4.3 K+ channels. 2002, Pubmed
Fedida, Modulation of slow inactivation in human cardiac Kv1.5 channels by extra- and intracellular permeant cations. 1999, Pubmed
Franqueza, Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits. 1999, Pubmed , Xenbase
Gómez-Lagunas, Shaker B K+ conductance in Na+ solutions lacking K+ ions: a remarkably stable non-conducting state produced by membrane depolarizations. 1997, Pubmed
Gómez-Lagunas, Na(+) interaction with the pore of Shaker B K(+) channels: zero and low K(+) conditions. 2001, Pubmed
Heginbotham, The aromatic binding site for tetraethylammonium ion on potassium channels. 1992, Pubmed
Heitzmann, Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells. 2004, Pubmed
Hoshi, Biophysical and molecular mechanisms of Shaker potassium channel inactivation. 1990, Pubmed , Xenbase
Hoshi, Two types of inactivation in Shaker K+ channels: effects of alterations in the carboxy-terminal region. 1991, Pubmed , Xenbase
Inoue, Activation-inactivation of potassium channels and development of the potassium-channel spike in internally perfused squid giant axons. 1981, Pubmed
Jensen, Inactivation as a new regulatory mechanism for neuronal Kv7 channels. 2007, Pubmed , Xenbase
Jiang, The open pore conformation of potassium channels. 2002, Pubmed
Jow, Functional coupling of intracellular calcium and inactivation of voltage-gated Kv1.1/Kvbeta1.1 A-type K+ channels. 2004, Pubmed , Xenbase
Klemic, Inactivation of Kv2.1 potassium channels. 1998, Pubmed , Xenbase
Klemic, U-type inactivation of Kv3.1 and Shaker potassium channels. 2001, Pubmed , Xenbase
Kurata, A structural interpretation of voltage-gated potassium channel inactivation. 2006, Pubmed
Kurokawa, TEA(+)-sensitive KCNQ1 constructs reveal pore-independent access to KCNE1 in assembled I(Ks) channels. 2001, Pubmed
Labro, Gating of shaker-type channels requires the flexibility of S6 caused by prolines. 2003, Pubmed
Lambrecht, Identification of the K efflux channel coupled to the gastric H-K-ATPase during acid secretion. 2005, Pubmed
Levy, Recovery from C-type inactivation is modulated by extracellular potassium. 1996, Pubmed
Li, Regulation of N- and C-type inactivation of Kv1.4 by pHo and K+: evidence for transmembrane communication. 2003, Pubmed , Xenbase
Lichtinghagen, Molecular basis of altered excitability in Shaker mutants of Drosophila melanogaster. 1990, Pubmed , Xenbase
Liu, Dynamic rearrangement of the outer mouth of a K+ channel during gating. 1996, Pubmed
Long, Voltage sensor of Kv1.2: structural basis of electromechanical coupling. 2005, Pubmed
Long, Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. 2005, Pubmed
Loots, Protein rearrangements underlying slow inactivation of the Shaker K+ channel. 1998, Pubmed
Loots, Molecular coupling of S4 to a K(+) channel's slow inactivation gate. 2000, Pubmed
Lu, Coupling between voltage sensors and activation gate in voltage-gated K+ channels. 2002, Pubmed , Xenbase
López-Barneo, Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. 1993, Pubmed , Xenbase
McCrossan, The MinK-related peptides. 2004, Pubmed , Xenbase
Melman, A single transmembrane site in the KCNE-encoded proteins controls the specificity of KvLQT1 channel gating. 2002, Pubmed
Melman, KCNE1 binds to the KCNQ1 pore to regulate potassium channel activity. 2004, Pubmed
Muramatsu, Mechanism of sodium channel block in crayfish giant axons by 711389-S, a new antiarrhythmic drug. 1987, Pubmed
Murrell-Lagnado, Interactions of amino terminal domains of Shaker K channels with a pore blocking site studied with synthetic peptides. 1993, Pubmed , Xenbase
Murrell-Lagnado, Energetics of Shaker K channels block by inactivation peptides. 1993, Pubmed , Xenbase
Neyroud, A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome. 1997, Pubmed
Nicolas, KCNQ1/KCNE1 potassium channels in mammalian vestibular dark cells. 2001, Pubmed
Ogielska, Functional consequences of a decreased potassium affinity in a potassium channel pore. Ion interactions and C-type inactivation. 1999, Pubmed , Xenbase
Ogielska, Cooperative subunit interactions in C-type inactivation of K channels. 1995, Pubmed , Xenbase
Olcese, Correlation between charge movement and ionic current during slow inactivation in Shaker K+ channels. 1997, Pubmed , Xenbase
Panaghie, Interaction of KCNE subunits with the KCNQ1 K+ channel pore. 2006, Pubmed , Xenbase
Panaghie, The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes. 2007, Pubmed , Xenbase
Pusch, Activation and inactivation of homomeric KvLQT1 potassium channels. 1998, Pubmed , Xenbase
Pusch, Two open states and rate-limiting gating steps revealed by intracellular Na+ block of human KCNQ1 and KCNQ1/KCNE1 K+ channels. 2001, Pubmed
Rasmusson, Inactivation of voltage-gated cardiac K+ channels. 1998, Pubmed
Robbins, KCNQ potassium channels: physiology, pathophysiology, and pharmacology. 2001, Pubmed
Roepke, The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion. 2006, Pubmed
Ruppersberg, Cloned neuronal IK(A) channels reopen during recovery from inactivation. 1991, Pubmed
Sanguinetti, Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. 1996, Pubmed , Xenbase
Sanguinetti, A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. 1995, Pubmed , Xenbase
Schroeder, A constitutively open potassium channel formed by KCNQ1 and KCNE3. 2000, Pubmed , Xenbase
Schwede, SWISS-MODEL: An automated protein homology-modeling server. 2003, Pubmed
Seebohm, Mutation of colocalized residues of the pore helix and transmembrane segments S5 and S6 disrupt deactivation and modify inactivation of KCNQ1 K+ channels. 2005, Pubmed , Xenbase
Seebohm, Differential roles of S6 domain hinges in the gating of KCNQ potassium channels. 2006, Pubmed , Xenbase
Seebohm, Tight coupling of rubidium conductance and inactivation in human KCNQ1 potassium channels. 2003, Pubmed , Xenbase
Sesti, Single-channel characteristics of wild-type IKs channels and channels formed with two minK mutants that cause long QT syndrome. 1998, Pubmed , Xenbase
Shimizu, Interaction between tetraethylammonium and permeant cations at the inactivation gate of the HERG potassium channel. 2003, Pubmed , Xenbase
Sigworth, Potassium channel mechanics. 2001, Pubmed
Smith, The inward rectification mechanism of the HERG cardiac potassium channel. 1996, Pubmed
Splawski, Molecular basis of the long-QT syndrome associated with deafness. 1997, Pubmed
Splawski, Mutations in the hminK gene cause long QT syndrome and suppress IKs function. 1997, Pubmed , Xenbase
Starkus, Voltage dependence of slow inactivation in Shaker potassium channels results from changes in relative K(+) and Na(+) permeabilities. 2000, Pubmed , Xenbase
Sukhareva, Constitutive activation of the Shaker Kv channel. 2003, Pubmed , Xenbase
Tristani-Firouzi, Voltage-dependent inactivation of the human K+ channel KvLQT1 is eliminated by association with minimal K+ channel (minK) subunits. 1998, Pubmed , Xenbase
Turrigiano, Cellular short-term memory from a slow potassium conductance. 1996, Pubmed
Wang, Gating charge immobilization caused by the transition between inactivated states in the Kv1.5 channel. 2001, Pubmed
Wang, Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. 1996, Pubmed
Webster, Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges. 2004, Pubmed
Yang, KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias. 1997, Pubmed , Xenbase
Yarov-Yarovoy, Voltage sensor conformations in the open and closed states in ROSETTA structural models of K(+) channels. 2006, Pubmed
Zhang, Gating charges in the activation and inactivation processes of the HERG channel. 2004, Pubmed , Xenbase