XB-ART-39008
Nat Cell Biol
January 1, 2009;
11
(1):
106-9.
Regulation of ERK activity duration by Sprouty contributes to dorsoventral patterning.
Abstract
Distinct modes of
ERK activation, sustained or transient, are essential for cell fate decision in cultured cells. Here we show that Xenopus laevis
Sprouty2 (XSpry2) controls the duration of
ERK activity and thereby contributes to the establishment of dorsoventral patterning during
mesoderm formation. Furthermore, Xenopus
Fos (XFos) can function as a molecular sensor of the
ERK signalling duration in Xenopus embryos. This work provides the first evidence that regulating the duration of
ERK activity contributes to cell fate decisions in the context of the whole organism.
PubMed ID:
19122596
Article link:
Nat Cell Biol
Species referenced:
Xenopus
Genes referenced:
fos
mapk1
spry1
spry2
Morpholinos:
fos MO1
spry1 MO2
spry2 MO2
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