XB-ART-39030Dev Dyn June 1, 2009; 238 (6): 1455-66.
Identification of embryonic pancreatic genes using Xenopus DNA microarrays.
The pancreas is both an exocrine and endocrine endodermal organ involved in digestion and glucose homeostasis. During embryogenesis, the anlagen of the pancreas arise from dorsal and ventral evaginations of the foregut that later fuse to form a single organ. To better understand the molecular genetics of early pancreas development, we sought to isolate markers that are uniquely expressed in this tissue. Microarray analysis was performed comparing dissected pancreatic buds, liver buds, and the stomach region of tadpole stage Xenopus embryos. A total of 912 genes were found to be differentially expressed between these organs during early stages of organogenesis. K-means clustering analysis predicted 120 of these genes to be specifically enriched in the pancreas. Of these, we report on the novel expression patterns of 24 genes. Our analyses implicate the involvement of previously unsuspected signaling pathways during early pancreas development. Developmental Dynamics 238:1455-1466, 2009. (c) 2009 Wiley-Liss, Inc.
PubMed ID: 19191222
PMC ID: PMC4203858
Article link: Dev Dyn
Genes referenced: btg1 cblb cdk17 cited2 cldn4 fgfr4 fubp1 fzd10 gjc1 hes3 hes5.2 hes5.3 ica1 kirrel2 mdk mlec nr5a2 pdcd4 plxnb1 plxnd1 rbpj reep5 rnd1 stxbp6 tent5c trim66 urb2
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