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XB-ART-3913
Mol Interv 2003 May 01;33:127-30. doi: 10.1124/mi.3.3.127.
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Aurora-A overexpression leads to override of the microtubule-kinetochore attachment checkpoint.

Dutertre S , Prigent C .


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The amplification of AURORA-A is frequently observed in specific epithelial cell malignancies. The overexpression of aurora-A, a Ser-Thr kinase known to localize to centrosomes during mitosis, appears to imbue cancerous cells with resistance to spindle-checkpoint-targeting drugs such as paclitaxel (Taxol). Indeed, a recent publication by Anand et al. indicates that overexpression of AURORA-A may interfere with spindle-microtubule attachment and disrupt the regulation of the spindle checkpoint by allowing cells with abnormal chromosomal separation to enter anaphase. Thus, the design of new drugs that specifically target aurora-A rather than other checkpoint proteins might alleviate the resistance to Taxol-like clinical therapeutics observed in some tumors.

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Species referenced: Xenopus
Genes referenced: aurka tbx2