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XB-ART-39210
Development. October 1, 2008; 135 (19): 3185-90.

GATA transcription factors integrate Wnt signalling during heart development.

Afouda BA , Martin J , Liu F , Ciau-Uitz A , Patient R , Hoppler S .


Abstract
Cardiogenesis is inhibited by canonical Wnt/beta-catenin signalling and stimulated by non-canonical Wnt11/JNK signalling, but how these two signalling pathways crosstalk is currently unknown. Here, we show that Wnt/beta-catenin signalling restricts cardiogenesis via inhibition of GATA gene expression, as experimentally reinstating GATA function overrides beta-catenin-mediated inhibition and restores cardiogenesis. Furthermore, we show that GATA transcription factors in turn directly regulate Wnt11 gene expression, and that Wnt11 is required to a significant degree for mediating the cardiogenesis-promoting function of GATA transcription factors. These results demonstrate that GATA factors occupy a central position between canonical and non-canonical Wnt signalling in regulating heart muscle formation.

PubMed ID: 18715946
Article link: Development.
Grant support: 071101/Z/03/Z Wellcome TrustBritish Heart Foundation , MC_U137981013 Medical Research Council , 071101/Z/03/Z Wellcome TrustBritish Heart Foundation , MRC_MC_U137981013 Medical Research Council , 071101/Z/03/Z Wellcome TrustBritish Heart Foundation , MC_U137981013 Medical Research Council , 071101/Z/03/Z Wellcome TrustBritish Heart Foundation

Genes referenced: dkk1 gata4 gata6 myh4 myh6 myl2 nkx2-5 tnni3 wnt11

Morpholinos referenced: wnt11b MO1

References:
Samuel, 2009, Pubmed, Xenbase


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