Comparative and developmental study of the immune system in Xenopus.
Xenopus laevis is the model of choice for evolutionary, comparative, and developmental studies of immunity, and invaluable research tools including MHC-defined clones, inbred strains, cell lines, and monoclonal antibodies are available for these studies. Recent efforts to use Silurana (Xenopus) tropicalis for genetic analyses have led to the sequencing of the whole genome. Ongoing genome mapping and mutagenesis studies will provide a new dimension to the study of immunity. Here we review what is known about the immune system of X. laevis integrated with available genomic information from S. tropicalis. This review provides compelling evidence for the high degree of similarity and evolutionary conservation between Xenopus and mammalian immune systems. We propose to build a powerful and innovative comparative biomedical model based on modern genetic technologies that takes take advantage of X. laevis and S. tropicalis, as well as the whole Xenopus genus. Developmental Dynamics 238:1249-1270, 2009. (c) 2009 Wiley-Liss, Inc.
PubMed ID: 19253402
PMC ID: PMC2892269
Article link: Dev Dyn.
Grant support: AI27877 NIAID NIH HHS , R01-CA-108982-02 NCI NIH HHS , R24-AI-059830 NIAID NIH HHS , R24 AI059830-05 NIAID NIH HHS , R24 AI059830-06 NIAID NIH HHS , R24 AI059830-08 NIAID NIH HHS , R24 AI059830 NIAID NIH HHS
Genes referenced: myh6
Antibodies referenced: CD5 Ab1 Cd3e Ab1 Cd8 Ab1 Cth Ab1 Cth Ab2 IgM Ab1 IgX Ab1 Leukocyte Ab1 Leukocyte Ab2 Leukocyte Ab3 Leukocyte Ab4 Leukocyte Ab5 Leukocyte Ab6 Leukocyte Ab7 Mhc1a Ab1 Mhc2a Ab1 Mhc2a Ab2 Ptprc Ab1