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Organogenesis October 1, 2007; 3 (2): 93-101.

Ets-1 regulates radial glia formation during vertebrate embryogenesis.

Kiyota T , Kato A , Kato Y .

Radial glia cells are the first distinguishable glial population derived from neural epithelial cells and serve as guides for migrating neurons and as neural progenitor cells in the developing brain. Despite their functional importance during neural development, the determination and differentiation of these cells remains poorly understood at the molecular level. Ets-1 and Ets-2, Ets (E26 transformation-specific) transcription factors, are vertebrate homologues of Drosophila pointed, which is expressed in a subset of glia cells and promotes different aspects of Drosophila glia cell differentiation. However, it remains unsolved that the function of Ets genes is conserved in vertebrate glia development. Here we report that Ets-1 but not Ets-2 is necessary for Xenopus radial glia formation and the activity of Ets-1 is sufficient for radial glia formation prior to neural tube closure. Furthermore, we show that Ras-MAPK (mitogen activated protein kinase) signaling, which acts as an upstream activator of Ets-1 in other biological processes, also regulates radial glia formation. A mutant form of Ets-1, which is not responsive to Ras-MAPK signaling, inhibits radial glia formation promoted by Ras-MAPK signaling. Together, our results show that Ets-1 activated by Ras-MAPK signaling promotes radial glia formation during Xenopus embryogenesis.

PubMed ID: 19279707
PMC ID: PMC2634171
Article link: Organogenesis

Genes referenced: ets1 ets2 gal.2 mapk1 nr3c1 nrp1 prph vim

Article Images: [+] show captions
References [+] :
Albagli, A model for gene evolution of the ets-1/ets-2 transcription factors based on structural and functional homologies. 1994, Pubmed

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