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Genes Dev May 1, 2009; 23 (9): 1046-51.

microRNA-24a is required to repress apoptosis in the developing neural retina.

Walker JC , Harland RM .

Programmed cell death is important for the proper development of the retina, and microRNAs (miRNAs) may be critical for its regulation. Here, we report that miR-24a is expressed in the neural retina and is required for correct eye morphogenesis in Xenopus. Inhibition of miR-24a during development causes a reduction in eye size due to a significant increase in apoptosis in the retina, whereas overexpression of miR-24a is sufficient to prevent apoptosis. We show that miR-24a negatively regulates the proapoptotic factors caspase9 and apaf1, demonstrating a role for miRNAs in the regulation of apoptosis during normal development.

PubMed ID: 19372388
PMC ID: PMC2682950
Article link: Genes Dev
Grant support: [+]
Genes referenced: apaf1 casp9

Article Images: [+] show captions
References [+] :
Cecconi, The involvement of cell death and survival in neural tube defects: a distinct role for apoptosis and autophagy? 2008, Pubmed

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