Due to necessary maintenance, Xenbase will be unavailable December 24-30, 2014. We apologize for the inconvenience.

Click on this message to dismiss it.
Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-39816
Trends Cell Biol. November 1, 2008; 18 (11): 517-20.

Dishevelled links basal body docking and orientation in ciliated epithelial cells.

Vladar EK , Axelrod JD .


Abstract
Some epithelia contain cells with multiple motile cilia that beat in a concerted manner. New tools and experimental systems have facilitated molecular studies of cilium biogenesis and the coordinated planar polarization of cilia that leads to their concerted motility. A recent elegant study using embryonic frog epidermis demonstrates that Dishevelled, a key regulator of both the Wnt-beta-catenin and planar cell polarity pathways, controls both the docking and planar polarization of ciliary basal bodies.

PubMed ID: 18819800
PMC ID: PMC3989925
Article link: Trends Cell Biol.
Grant support: T32-CA09151 NCI NIH HHS , T32-CA09151 NCI NIH HHS , T32-CA09151 NCI NIH HHS , T32-CA09151 NCI NIH HHS , T32-CA09151 NCI NIH HHS , T32-CA09151 NCI NIH HHS , R01 GM059823 NIGMS NIH HHS , T32 CA009151 NCI NIH HHS , T32 CA009151 NCI NIH HHS , T32 CA009151 NCI NIH HHS , T32 CA009151 NCI NIH HHS , T32 CA009151 NCI NIH HHS , T32 CA009151 NCI NIH HHS

Genes referenced: dvl2
Antibodies referenced:
Morpholinos referenced:

My Xenbase: [ Log-in / Register ]
version: [3.3.1]


Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556