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XB-ART-39816
Trends Cell Biol 2008 Nov 01;1811:517-20. doi: 10.1016/j.tcb.2008.08.004.
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Dishevelled links basal body docking and orientation in ciliated epithelial cells.

Vladar EK , Axelrod JD .


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Some epithelia contain cells with multiple motile cilia that beat in a concerted manner. New tools and experimental systems have facilitated molecular studies of cilium biogenesis and the coordinated planar polarization of cilia that leads to their concerted motility. A recent elegant study using embryonic frog epidermis demonstrates that Dishevelled, a key regulator of both the Wnt-beta-catenin and planar cell polarity pathways, controls both the docking and planar polarization of ciliary basal bodies.

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Species referenced: Xenopus laevis
Genes referenced: dvl2

References [+] :
Boisvieux-Ulrich, The orientation of ciliary basal bodies in quail oviduct is related to the ciliary beating cycle commencement. 1985, Pubmed