Dishevelled links basal body docking and orientation in ciliated epithelial cells.
Some epithelia contain cells with multiple motile cilia that beat in a concerted manner. New tools and experimental systems have facilitated molecular studies of cilium biogenesis and the coordinated planar polarization of cilia that leads to their concerted motility. A recent elegant study using embryonic frog epidermis demonstrates that Dishevelled, a key regulator of both the Wnt-beta-catenin and planar cell polarity pathways, controls both the docking and planar polarization of ciliary basal bodies.
PubMed ID: 18819800
PMC ID: PMC3989925
Article link: Trends Cell Biol.
Grant support: T32-CA09151 NCI NIH HHS , R01 GM059823 NIGMS NIH HHS , T32 CA009151 NCI NIH HHS
Genes referenced: dvl2