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Neuron
2009 May 28;624:526-38. doi: 10.1016/j.neuron.2009.04.013.
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A tyramine-gated chloride channel coordinates distinct motor programs of a Caenorhabditis elegans escape response.
Pirri JK
,
McPherson AD
,
Donnelly JL
,
Francis MM
,
Alkema MJ
.
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A key feature of escape responses is the fast translation of sensory information into a coordinated motor output. In C. elegans, anterior touch initiates a backward escape response in which lateralhead movements are suppressed. Here, we show that tyramine inhibits head movements and forward locomotion through the activation of a tyramine-gated chloride channel, LGC-55. lgc-55 mutant animals have defects in reversal behavior and fail to suppress head oscillations in response to anterior touch. lgc-55 is expressed in neurons and muscle cells that receive direct synaptic inputs from tyraminergic motor neurons. Therefore, tyramine can act as a classical inhibitory neurotransmitter. Activation of LGC-55 by tyramine coordinates the output of two distinct motor programs, locomotion and head movements that are critical for a C. elegans escape response.
Alkema,
Tyramine Functions independently of octopamine in the Caenorhabditis elegans nervous system.
2005, Pubmed
Alkema,
Tyramine Functions independently of octopamine in the Caenorhabditis elegans nervous system.
2005,
Pubmed
Allen,
Making an escape: development and function of the Drosophila giant fibre system.
2006,
Pubmed
Altun-Gultekin,
A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans.
2001,
Pubmed
Bamber,
The Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor.
1999,
Pubmed
,
Xenbase
Betz,
Ligand-gated ion channels in the brain: the amino acid receptor superfamily.
1990,
Pubmed
Blenau,
Amtyr1: characterization of a gene from honeybee (Apis mellifera) brain encoding a functional tyramine receptor.
2000,
Pubmed
Blumenthal,
Modulation of tyramine signaling by osmolality in an insect secretory epithelium.
2005,
Pubmed
Borowsky,
Trace amines: identification of a family of mammalian G protein-coupled receptors.
2001,
Pubmed
Branicky,
Tyramine: a new receptor and a new role at the synapse.
2009,
Pubmed
Brembs,
Flight initiation and maintenance deficits in flies with genetically altered biogenic amine levels.
2007,
Pubmed
Brenner,
The genetics of Caenorhabditis elegans.
1974,
Pubmed
Card,
Performance trade-offs in the flight initiation of Drosophila.
2008,
Pubmed
Chalfie,
The neural circuit for touch sensitivity in Caenorhabditis elegans.
1985,
Pubmed
Chalfie,
Developmental genetics of the mechanosensory neurons of Caenorhabditis elegans.
1981,
Pubmed
Chalfie,
Green fluorescent protein as a marker for gene expression.
1994,
Pubmed
Chronis,
Microfluidics for in vivo imaging of neuronal and behavioral activity in Caenorhabditis elegans.
2007,
Pubmed
Cole,
Two functional but noncomplementing Drosophila tyrosine decarboxylase genes: distinct roles for neural tyramine and octopamine in female fertility.
2005,
Pubmed
Davis,
Rapid single nucleotide polymorphism mapping in C. elegans.
2005,
Pubmed
Edwards,
Metamodulation of the crayfish escape circuit.
2002,
Pubmed
Francis,
Electrophysiological analysis of neuronal and muscle function in C. elegans.
2006,
Pubmed
Gray,
A circuit for navigation in Caenorhabditis elegans.
2005,
Pubmed
Green,
The role of the cystine loop in acetylcholine receptor assembly.
1997,
Pubmed
Grutter,
Molecular tuning of fast gating in pentameric ligand-gated ion channels.
2005,
Pubmed
Hammond,
Escape flight initiation in the fly.
2007,
Pubmed
Hart,
Synaptic code for sensory modalities revealed by C. elegans GLR-1 glutamate receptor.
1995,
Pubmed
Henwood,
Iontophoretic studies of some trace amines in the mammalian CNS.
1979,
Pubmed
Isaac,
Metabolism and inactivation of neurotransmitters in nematodes.
1996,
Pubmed
Jones,
The cys-loop ligand-gated ion channel gene superfamily of the nematode, Caenorhabditis elegans.
2008,
Pubmed
Karlin,
Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins.
1995,
Pubmed
Katz,
Dynamic neuromodulation of synaptic strength intrinsic to a central pattern generator circuit.
1994,
Pubmed
Korn,
The Mauthner cell half a century later: a neurobiological model for decision-making?
2005,
Pubmed
Marder,
Central pattern generators and the control of rhythmic movements.
2001,
Pubmed
Maricq,
Mechanosensory signalling in C. elegans mediated by the GLR-1 glutamate receptor.
1995,
Pubmed
McIntire,
The GABAergic nervous system of Caenorhabditis elegans.
1993,
Pubmed
Mellem,
Action potentials contribute to neuronal signaling in C. elegans.
2008,
Pubmed
Miller,
Primate trace amine receptor 1 modulation by the dopamine transporter.
2005,
Pubmed
Monastirioti,
Characterization of Drosophila tyramine beta-hydroxylase gene and isolation of mutant flies lacking octopamine.
1996,
Pubmed
Mullen,
The Caenorhabditis elegans snf-11 gene encodes a sodium-dependent GABA transporter required for clearance of synaptic GABA.
2006,
Pubmed
Nusbaum,
A small-systems approach to motor pattern generation.
2002,
Pubmed
Ohta,
B96Bom encodes a Bombyx mori tyramine receptor negatively coupled to adenylate cyclase.
2003,
Pubmed
Okkema,
Sequence requirements for myosin gene expression and regulation in Caenorhabditis elegans.
1993,
Pubmed
Ortells,
Evolutionary history of the ligand-gated ion-channel superfamily of receptors.
1995,
Pubmed
PATON,
Central and synaptic transmission in the nervous system; pharmacological aspects.
1958,
Pubmed
Phelan,
Mutations in shaking-B prevent electrical synapse formation in the Drosophila giant fiber system.
1996,
Pubmed
Ranganathan,
MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans.
2000,
Pubmed
,
Xenbase
Rex,
TYRA-2 (F01E11.5): a Caenorhabditis elegans tyramine receptor expressed in the MC and NSM pharyngeal neurons.
2005,
Pubmed
Rex,
Characterization of a tyramine receptor from Caenorhabditis elegans.
2002,
Pubmed
Roeder,
Tyramine and octopamine: antagonistic modulators of behavior and metabolism.
2003,
Pubmed
Sagasti,
Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4.
1999,
Pubmed
Saudou,
Cloning and characterization of a Drosophila tyramine receptor.
1990,
Pubmed
Shaner,
Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein.
2004,
Pubmed
Tanouye,
Motor outputs of giant nerve fiber in Drosophila.
1980,
Pubmed
Thorn,
Carnivorous mushrooms.
1984,
Pubmed
Tsalik,
LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system.
2003,
Pubmed
Weber,
Ion currents of Xenopus laevis oocytes: state of the art.
1999,
Pubmed
,
Xenbase
White,
The structure of the nervous system of the nematode Caenorhabditis elegans.
1986,
Pubmed
Wicks,
Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map.
2001,
Pubmed
Wragg,
Tyramine and octopamine independently inhibit serotonin-stimulated aversive behaviors in Caenorhabditis elegans through two novel amine receptors.
2007,
Pubmed
Zhao,
Reversal frequency in Caenorhabditis elegans represents an integrated response to the state of the animal and its environment.
2003,
Pubmed
Zheng,
Neuronal control of locomotion in C. elegans is modified by a dominant mutation in the GLR-1 ionotropic glutamate receptor.
1999,
Pubmed
Zhu,
Tyramine excites rat subthalamic neurons in vitro by a dopamine-dependent mechanism.
2007,
Pubmed
Zumstein,
Distance and force production during jumping in wild-type and mutant Drosophila melanogaster.
2004,
Pubmed
