XB-ART-39981
Chromosome Res
2009 Jan 01;172:131-44. doi: 10.1007/s10577-008-9009-7.
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Condensin: Architect of mitotic chromosomes.
Hudson DF
,
Marshall KM
,
Earnshaw WC
.
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Condensin is a highly conserved pentameric complex consisting of two structural maintenance of chromosome (SMC) ATPase subunits and three auxiliary components. While initially regarded as a key driver of mitotic chromosome condensation, condensin is increasingly viewed as having a more subtle influence on chromosome architecture. The two condensin complexes are required to direct the correct folding and organization of chromosomes prior to anaphase and for keeping the chromosomes compact as they separate to the poles. This ancient complex is essential in mitosis and meiosis and has additional roles in gene regulation and DNA repair. The wide variety of biochemical and genetic tools available are gradually unravelling the numerous roles condensin plays during the cell cycle and shedding light on its mechanism of action.
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Species referenced: Xenopus laevis
References [+] :
Adams,
Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation.
2001, Pubmed
Adams, Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation. 2001, Pubmed
Adolph, Role of nonhistone proteins in metaphase chromosome structure. 1977, Pubmed
Anderson, Condensin and cohesin display different arm conformations with characteristic hinge angles. 2002, Pubmed , Xenbase
Arumugam, ATP hydrolysis is required for cohesin's association with chromosomes. 2003, Pubmed
Arumugam, Cohesin's ATPase activity is stimulated by the C-terminal Winged-Helix domain of its kleisin subunit. 2006, Pubmed
Bazett-Jones, Efficient supercoiling of DNA by a single condensin complex as revealed by electron spectroscopic imaging. 2002, Pubmed , Xenbase
Belmont, Mitotic chromosome structure and condensation. 2006, Pubmed
Chuang, DPY-27:a chromosome condensation protein homolog that regulates C. elegans dosage compensation through association with the X chromosome. 1994, Pubmed , Xenbase
Cobbe, The evolution of SMC proteins: phylogenetic analysis and structural implications. 2004, Pubmed
Csankovszki, Three distinct condensin complexes control C. elegans chromosome dynamics. 2009, Pubmed
D'Ambrosio, Identification of cis-acting sites for condensin loading onto budding yeast chromosomes. 2008, Pubmed
Earnshaw, Architecture of metaphase chromosomes and chromosome scaffolds. 1983, Pubmed
Earnshaw, Topoisomerase II is a structural component of mitotic chromosome scaffolds. 1985, Pubmed
Eide, Distinct but overlapping domains of AKAP95 are implicated in chromosome condensation and condensin targeting. 2002, Pubmed , Xenbase
Gasser, Metaphase chromosome structure. Involvement of topoisomerase II. 1986, Pubmed
Gerlich, Condensin I stabilizes chromosomes mechanically through a dynamic interaction in live cells. 2006, Pubmed
Giet, Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis. 2001, Pubmed
Gruber, Chromosomal cohesin forms a ring. 2003, Pubmed
Gruber, Evidence that loading of cohesin onto chromosomes involves opening of its SMC hinge. 2006, Pubmed
Haering, Structure and stability of cohesin's Smc1-kleisin interaction. 2004, Pubmed
Haering, The cohesin ring concatenates sister DNA molecules. 2008, Pubmed
Haering, Molecular architecture of SMC proteins and the yeast cohesin complex. 2002, Pubmed
Hagstrom, C. elegans condensin promotes mitotic chromosome architecture, centromere organization, and sister chromatid segregation during mitosis and meiosis. 2002, Pubmed , Xenbase
Hirano, Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein. 1997, Pubmed , Xenbase
Hirano, At the heart of the chromosome: SMC proteins in action. 2006, Pubmed
Hirano, Bimodal activation of SMC ATPase by intra- and inter-molecular interactions. 2001, Pubmed
Hirano, A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitro. 1994, Pubmed , Xenbase
Hirano, Condensins: organizing and segregating the genome. 2005, Pubmed
Hirano, Opening closed arms: long-distance activation of SMC ATPase by hinge-DNA interactions. 2006, Pubmed
Hirano, Isolation and characterization of Schizosaccharomyces pombe cutmutants that block nuclear division but not cytokinesis. 1986, Pubmed
Hirota, Distinct functions of condensin I and II in mitotic chromosome assembly. 2004, Pubmed
Hopfner, Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase. 2001, Pubmed
Hudson, Molecular and genetic analysis of condensin function in vertebrate cells. 2008, Pubmed
Hudson, Condensin is required for nonhistone protein assembly and structural integrity of vertebrate mitotic chromosomes. 2003, Pubmed
Kaitna, The aurora B kinase AIR-2 regulates kinetochores during mitosis and is required for separation of homologous Chromosomes during meiosis. 2002, Pubmed
Kimura, 13S condensin actively reconfigures DNA by introducing global positive writhe: implications for chromosome condensation. 1999, Pubmed , Xenbase
Kimura, Dual roles of the 11S regulatory subcomplex in condensin functions. 2000, Pubmed , Xenbase
Koshland, Mitotic chromosome condensation. 1996, Pubmed
Laemmli, Scaffold-associated regions: cis-acting determinants of chromatin structural loops and functional domains. 1992, Pubmed
Lavoie, In vivo requirements for rDNA chromosome condensation reveal two cell-cycle-regulated pathways for mitotic chromosome folding. 2004, Pubmed , Xenbase
Lewis, Higher order metaphase chromosome structure: evidence for metalloprotein interactions. 1982, Pubmed
Lipp, Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes. 2007, Pubmed
Longworth, RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3. 2008, Pubmed
Maeshima, A two-step scaffolding model for mitotic chromosome assembly. 2003, Pubmed
Melby, The symmetrical structure of structural maintenance of chromosomes (SMC) and MukB proteins: long, antiparallel coiled coils, folded at a flexible hinge. 1998, Pubmed
Murnion, Chromatin-associated protein phosphatase 1 regulates aurora-B and histone H3 phosphorylation. 2001, Pubmed , Xenbase
Nakazawa, Dissection of the essential steps for condensin accumulation at kinetochores and rDNAs during fission yeast mitosis. 2008, Pubmed
Nasmyth, The structure and function of SMC and kleisin complexes. 2005, Pubmed
Oliveira, The condensin I subunit Barren/CAP-H is essential for the structural integrity of centromeric heterochromatin during mitosis. 2005, Pubmed
Onn, Reconstitution and subunit geometry of human condensin complexes. 2007, Pubmed , Xenbase
Ono, Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells. 2003, Pubmed , Xenbase
Ono, Spatial and temporal regulation of Condensins I and II in mitotic chromosome assembly in human cells. 2004, Pubmed
Parelho, Cohesins functionally associate with CTCF on mammalian chromosome arms. 2008, Pubmed
Paulson, The structure of histone-depleted metaphase chromosomes. 1977, Pubmed
Poirier, Mitotic chromosomes are chromatin networks without a mechanically contiguous protein scaffold. 2002, Pubmed
Ribeiro, Condensin regulates the stiffness of vertebrate centromeres. 2009, Pubmed
Saitoh, ScII: an abundant chromosome scaffold protein is a member of a family of putative ATPases with an unusual predicted tertiary structure. 1994, Pubmed
Saitoh, The SMC proteins and the coming of age of the chromosome scaffold hypothesis. 1995, Pubmed , Xenbase
Schleiffer, Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners. 2003, Pubmed
Stray, Biochemical analysis of the yeast condensin Smc2/4 complex: an ATPase that promotes knotting of circular DNA. 2003, Pubmed , Xenbase
Strunnikov, SMC2, a Saccharomyces cerevisiae gene essential for chromosome segregation and condensation, defines a subgroup within the SMC family. 1995, Pubmed
Surcel, Cohesin interaction with centromeric minichromosomes shows a multi-complex rod-shaped structure. 2008, Pubmed
Takemoto, Negative regulation of condensin I by CK2-mediated phosphorylation. 2006, Pubmed , Xenbase
Takemoto, Cell cycle-dependent phosphorylation, nuclear localization, and activation of human condensin. 2004, Pubmed
Trinkle-Mulcahy, Repo-Man recruits PP1 gamma to chromatin and is essential for cell viability. 2006, Pubmed
Vagnarelli, Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis. 2006, Pubmed
Volkov, A prokaryotic condensin/cohesin-like complex can actively compact chromosomes from a single position on the nucleoid and binds to DNA as a ring-like structure. 2003, Pubmed
Wang, Condensin binding at distinct and specific chromosomal sites in the Saccharomyces cerevisiae genome. 2005, Pubmed
Weitzer, A model for ATP hydrolysis-dependent binding of cohesin to DNA. 2003, Pubmed
Wendt, Cohesin mediates transcriptional insulation by CCCTC-binding factor. 2008, Pubmed
Yeong, Identification of a subunit of a novel Kleisin-beta/SMC complex as a potential substrate of protein phosphatase 2A. 2003, Pubmed
Yoshimura, Condensin architecture and interaction with DNA: regulatory non-SMC subunits bind to the head of SMC heterodimer. 2002, Pubmed