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Genes Cells August 1, 2009; 14 (8): 941-7.

Neither MafA/L-Maf nor MafB is essential for lens development in mice.

Takeuchi T , Kudo T , Ogata K , Hamada M , Nakamura M , Kito K , Abe Y , Ueda N , Yamamoto M , Engel JD , Takahashi S .

The importance of the large Maf transcription factor family has been investigated in lens development in the chick, Xenopus and mammals. Previously we reported that c-maf-deficient mice exhibit severe defects in lens fibre cells. Here, we report the roles of other large Mafs, MafA/L-Maf and MafB, during mouse lens development. MafA/L-Maf and MafB were expressed in lens epithelial cells and fibre cells at E12.5 but had largely disappeared from the lens at E18.5. The lens of mafA-, mafB-deficient and mafA::mafB double-deficient mice developed normally. In c-maf-deficient mice, the pattern of expression of MafA and MafB differed from their expression in wild-type mice. Moreover, the expression of crystallin genes was unchanged in mafA-, mafB- and mafA::mafB double-deficient lens. These results indicate that c-Maf alone is essential for lens development, and that MafA/L-Maf and MafB are dispensable in mice.

PubMed ID: 19624757
Article link: Genes Cells

Genes referenced: maf mafa mafb nrl tcf3

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