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XB-ART-40141
Dev Dyn September 1, 2009; 238 (9): 2340-56.

Gene expression profiles of lens regeneration and development in Xenopus laevis.

Malloch EL , Perry KJ , Fukui L , Johnson VR , Wever J , Beck CW , King MW , Henry JJ .


Abstract
Seven hundred and thirty-four unique genes were recovered from a cDNA library enriched for genes up-regulated during the process of lens regeneration in the frog Xenopus laevis. The sequences represent transcription factors, proteins involved in RNA synthesis/processing, components of prominent cell signaling pathways, genes involved in protein processing, transport, and degradation (e.g., the ubiquitin/proteasome pathway), matrix metalloproteases (MMPs), as well as many other proteins. The findings implicate specific signal transduction pathways in the process of lens regeneration, including the FGF, TGF-beta, MAPK, Retinoic acid, Wnt, and hedgehog signaling pathways, which are known to play important roles in eye/lens development and regeneration in various systems. In situ hybridization revealed that the majority of genes recovered are expressed during embryogenesis, including in eye tissues. Several novel genes specifically expressed in lenses were identified. The suite of genes was compared to those up-regulated in other regenerating tissues/organisms, and a small degree of overlap was detected.

PubMed ID: 19681139
PMC ID: PMC2773617
Article link: Dev Dyn
Grant support: [+]
Genes referenced: lmo4.2 anos1 gpr84 ckb taf9b pheta2 ino80d prpf39.1 pym1 cmtm5 mmp1 cryga prps1 paxbp1 crygn cryba1 ids lmo4.1 pax3 pax7 smpd3 tgfb1
GO Terms: lens development in camera-type eye [+]


Article Images: [+] show captions
References:
Altschul, 1997, Pubmed [+]


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