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XB-ART-40170
Dev Dyn September 1, 2009; 238 (9): 2382-7.

Xmc mediates Xctr1-independent morphogenesis in Xenopus laevis.



Abstract
In the frog, Xenopus laevis, fibroblast growth factor (FGF) signaling is required for both mesoderm formation and the morphogenetic movements that drive the elongation of the notochord, a dorsal mesodermal derivative; the coordination of these distinct roles is mediated by the Xenopus Ctr1 (Xctr1) protein: maternal Xctr1 is required for mesodermal differentiation, while the subsequent loss of Xctr1 promotes morphogenesis. The signaling cascade activated by FGF in the presence of Ctr1 has been well characterized; however, the Xctr1-independent, FGF-responsive network remains poorly defined. We have identified Xenopus Marginal Coil (Xmc) as a gene whose expression is highly enriched following Xctr1 knockdown. Zygotic initiation of Xmc expression in vivo coincides with a decrease in maternal Xctr1 transcripts; moreover, Xmc loss-of-function inhibits Xctr1 knockdown-mediated elongation of FGF-treated animal cap explants, implicating Xmc as a key effector of Xctr1-independent gastrular morphogenesis.

PubMed ID: 19653324
PMC ID: PMC2782962
Article link: Dev Dyn
Grant support: [+]

Species referenced: Xenopus
Genes referenced: acta4 actc1 actl6a aldoc arhgap21 atf5 ccnb1 cdca9 cldn6.1 dynll2 fgf2 gal.2 gbx2.1 hes5.10 hoxb9 khdrbs1 mthfd2 myc npm1 odc1 otx2 pcbd1 pou5f3.3 ppm1d rgma slc31a1 tbx2 ventx2.1 xmc zp2


Article Images: [+] show captions
References [+] :
Bassez, Post-transcriptional regulation of ornithine decarboxylase in Xenopus laevis oocytes. 1991, Pubmed, Xenbase