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XB-ART-40205
Dev Cell August 1, 2009; 17 (2): 222-33.

PAR-1 phosphorylates Mind bomb to promote vertebrate neurogenesis.

Ossipova O , Ezan J , Sokol SY .


Abstract
Generation of neurons in the vertebrate central nervous system requires a complex transcriptional regulatory network and signaling processes in polarized neuroepithelial progenitor cells. Here we demonstrate that neurogenesis in the Xenopus neural plate in vivo and mammalian neural progenitors in vitro involves intrinsic antagonistic activities of the polarity proteins PAR-1 and aPKC. Furthermore, we show that Mind bomb (Mib), a ubiquitin ligase that promotes Notch ligand trafficking and activity, is a crucial molecular substrate for PAR-1. The phosphorylation of Mib by PAR-1 results in Mib degradation, repression of Notch signaling, and stimulation of neuronal differentiation. These observations suggest a conserved mechanism for neuronal fate determination that might operate during asymmetric divisions of polarized neural progenitor cells.

PubMed ID: 19686683
PMC ID: PMC2849776
Article link: Dev Cell
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: bmp7.1 bmp7.2 dll1 mark2 mark3 mib1 notch1 prkci sox2 sox3 tubb2b wwc2
Morpholinos: mark2 MO1


Article Images: [+] show captions
References [+] :
Androutsellis-Theotokis, Notch signalling regulates stem cell numbers in vitro and in vivo. 2006, Pubmed