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Nature. September 3, 2009; 461 (7260): E1; discussion E2.

Scaling of BMP gradients in Xenopus embryos.

Francois P , Vonica A , Brivanlou AH , Siggia ED .

Metazoan organisms can ''scale'', that is, maintain similar proportions regardless of size. Ben-Zvi et al. use experiments in Xenopus to support a quantitative model that explains morphological scaling as the result of scaling of a gradient of bone morphogenetic protein (BMP) signals. We believe that the evidence for scaling in Xenopus is misinterpreted, and that their model for embryonic patterning disagrees with prior data. The experiments they present supporting their model admit alternative interpretations.

PubMed ID: 19736667
Article link:

Genes referenced: gtf2ird1 tbx2

External Resources:

Ben-Zvi, 2008, Pubmed, Xenbase[+]

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