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XB-ART-40311
Drug Discov Today Dis Models January 1, 2008; 5 (3): 141-146.

Lessons from the lily pad: Using Xenopus to understand heart disease.

Bartlett HL , Weeks DL .


Abstract
The developing embryos of the South African (Xenopus laevis) and Western (Xenopus tropicalis) clawed frogs provide an experimentally tractable and easily visualized model for vertebrate cardiovascular development. Most of the genes used to execute the cardiac developmental program are the same in frogs and humans. Experiments using Xenopus provide an underutilized but valuable complement to studies on the molecular, cellular, physiological and morphological consequences of genetic and environmental influences on cardiac disease.

PubMed ID: 19802378
PMC ID: PMC2747104
Article link: Drug Discov Today Dis Models
Grant support: [+]
Genes referenced: gata4 nkx2-5 nkx2-6 pitx2 tbx20 tbx5
GO keywords: heart looping [+]

Disease Ontology terms: Holt-Oram syndrome [+]
OMIMs: HOLT-ORAM SYNDROME; HOS [+]
References [+] :
Allen, Transgenic Xenopus laevis embryos can be generated using phiC31 integrase. 2005, Pubmed, Xenbase


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