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Drug Discov Today Dis Models. January 1, 2008; 5 (3): 141-146.

Lessons from the lily pad: Using Xenopus to understand heart disease.

The developing embryos of the South African (Xenopus laevis) and Western (Xenopus tropicalis) clawed frogs provide an experimentally tractable and easily visualized model for vertebrate cardiovascular development. Most of the genes used to execute the cardiac developmental program are the same in frogs and humans. Experiments using Xenopus provide an underutilized but valuable complement to studies on the molecular, cellular, physiological and morphological consequences of genetic and environmental influences on cardiac disease.

PubMed ID: 19802378
PMC ID: PMC2747104
Article link: Drug Discov Today Dis Models.
Grant support: R01 GM069944-04 NIGMS NIH HHS , R01 GM069944 NIGMS NIH HHS

Genes referenced: gata4 nkx2-5 nkx2-6 pitx2 tbx20 tbx5

Disease Ontology references: Holt-Oram syndrome [+]


External Resources: GO Terms referenced: heart looping [+]

Allen, 2005, Pubmed, Xenbase [+]

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Major funding for Xenbase is provided by the National Institute of Child Health and Human Development, grant P41 HD064556